Abstract
Efforts directed to identifying potent HIV protease inhibitors (PI) have yielded a class of compounds that are not only very active against wild-type (NL4-3) HIV virus but also very potent against a panel of PI-resistant viral isolates. Chemistry and biology are described.
MeSH terms
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Administration, Oral
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Biological Availability
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Drug Resistance, Viral
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HIV / drug effects*
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HIV / enzymology
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HIV Protease / drug effects
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HIV Protease Inhibitors / administration & dosage
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HIV Protease Inhibitors / chemistry*
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HIV Protease Inhibitors / pharmacology*
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Indinavir / analogs & derivatives*
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Molecular Structure
Substances
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HIV Protease Inhibitors
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Indinavir
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HIV Protease