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Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
Lu Z, Bohn J, Rano T, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR. Lu Z, et al. Among authors: chapman k. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5311-4. doi: 10.1016/j.bmcl.2005.08.072. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203148
A combinatorial library of indinavir analogues and its in vitro and in vivo studies.
Cheng Y, Rano TA, Huening TT, Zhang F, Lu Z, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Kuo LC, Lin JH, Xu X, Jin L, Olah TV, McLoughlin DA, King RC, Chapman KT, Tata JR. Cheng Y, et al. Bioorg Med Chem Lett. 2002 Feb 25;12(4):529-32. doi: 10.1016/s0960-894x(01)00824-1. Bioorg Med Chem Lett. 2002. PMID: 11844665
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Lynch CL, Hale JJ, Budhu RJ, Gentry AL, Mills SG, Chapman KT, MacCoss M, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Cascieri MA, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller M, Emini EA. Lynch CL, et al. Among authors: chapman kt. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3001-4. doi: 10.1016/s0960-894x(02)00606-6. Bioorg Med Chem Lett. 2002. PMID: 12270193
1,984 results