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The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Wiedmann RM, von Schwarzenberg K, Palamidessi A, Schreiner L, Kubisch R, Liebl J, Schempp C, Trauner D, Vereb G, Zahler S, Wagner E, Müller R, Scita G, Vollmar AM. Wiedmann RM, et al. Among authors: von schwarzenberg k. Cancer Res. 2012 Nov 15;72(22):5976-87. doi: 10.1158/0008-5472.CAN-12-1772. Epub 2012 Sep 17. Cancer Res. 2012. PMID: 22986742
MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition.
Schneider LS, Ulrich M, Lehr T, Menche D, Müller R, von Schwarzenberg K. Schneider LS, et al. Among authors: von schwarzenberg k. Mol Oncol. 2016 Aug;10(7):1054-62. doi: 10.1016/j.molonc.2016.04.005. Epub 2016 Apr 27. Mol Oncol. 2016. PMID: 27157929 Free PMC article.
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