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Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, Veit F, Scheibe S, Pichl A, Weisel F, Lloyd KC, Jaksch P, Klepetko W, Weissmann N, von Melchner H. Heidler J, et al. Among authors: von melchner h. Dis Model Mech. 2013 Nov;6(6):1378-87. doi: 10.1242/dmm.013482. Epub 2013 Aug 29. Dis Model Mech. 2013. PMID: 24046361 Free PMC article.
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, Schnütgen F, Scheibe S, Seimetz M, Jaksch P, Hyman A, Weissmann N, von Melchner H. Tomasovic A, et al. Among authors: von melchner h. J Biol Chem. 2015 Apr 10;290(15):9738-52. doi: 10.1074/jbc.M114.632133. Epub 2015 Feb 25. J Biol Chem. 2015. PMID: 25716320 Free PMC article.
Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.
Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H. Sterner-Kock A, et al. Among authors: von melchner h. Genes Dev. 2002 Sep 1;16(17):2264-73. doi: 10.1101/gad.229102. Genes Dev. 2002. PMID: 12208849 Free PMC article.
TGF-beta activation by traction?
Keski-Oja J, Koli K, von Melchner H. Keski-Oja J, et al. Among authors: von melchner h. Trends Cell Biol. 2004 Dec;14(12):657-9. doi: 10.1016/j.tcb.2004.10.003. Trends Cell Biol. 2004. PMID: 15564041 Review.
Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.
Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A. Bultmann-Mellin I, et al. Among authors: von melchner h. Dis Model Mech. 2015 Apr;8(4):403-15. doi: 10.1242/dmm.018960. Epub 2015 Feb 20. Dis Model Mech. 2015. PMID: 25713297 Free PMC article.
Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice.
Bultmann-Mellin I, Essers J, van Heijingen PM, von Melchner H, Sengle G, Sterner-Kock A. Bultmann-Mellin I, et al. Among authors: von melchner h. Dis Model Mech. 2016 Nov 1;9(11):1367-1374. doi: 10.1242/dmm.026005. Epub 2016 Sep 1. Dis Model Mech. 2016. PMID: 27585882 Free PMC article.
Gene-trap vectors and mutagenesis.
De-Zolt S, Altschmied J, Ruiz P, von Melchner H, Schnütgen F. De-Zolt S, et al. Among authors: von melchner h. Methods Mol Biol. 2009;530:29-47. doi: 10.1007/978-1-59745-471-1_3. Methods Mol Biol. 2009. PMID: 19266330
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