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Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, Veit F, Scheibe S, Pichl A, Weisel F, Lloyd KC, Jaksch P, Klepetko W, Weissmann N, von Melchner H. Heidler J, et al. Among authors: von melchner h. Dis Model Mech. 2013 Nov;6(6):1378-87. doi: 10.1242/dmm.013482. Epub 2013 Aug 29. Dis Model Mech. 2013. PMID: 24046361 Free PMC article.
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, Schnütgen F, Scheibe S, Seimetz M, Jaksch P, Hyman A, Weissmann N, von Melchner H. Tomasovic A, et al. Among authors: von melchner h. J Biol Chem. 2015 Apr 10;290(15):9738-52. doi: 10.1074/jbc.M114.632133. Epub 2015 Feb 25. J Biol Chem. 2015. PMID: 25716320 Free PMC article.
Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.
Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H. Sterner-Kock A, et al. Among authors: von melchner h. Genes Dev. 2002 Sep 1;16(17):2264-73. doi: 10.1101/gad.229102. Genes Dev. 2002. PMID: 12208849 Free PMC article.
Wnt/beta-catenin signaling controls development of the blood-brain barrier.
Liebner S, Corada M, Bangsow T, Babbage J, Taddei A, Czupalla CJ, Reis M, Felici A, Wolburg H, Fruttiger M, Taketo MM, von Melchner H, Plate KH, Gerhardt H, Dejana E. Liebner S, et al. Among authors: von melchner h. J Cell Biol. 2008 Nov 3;183(3):409-17. doi: 10.1083/jcb.200806024. Epub 2008 Oct 27. J Cell Biol. 2008. PMID: 18955553 Free PMC article.
Enhanced gene trapping in mouse embryonic stem cells.
Schnütgen F, Hansen J, De-Zolt S, Horn C, Lutz M, Floss T, Wurst W, Noppinger PR, von Melchner H. Schnütgen F, et al. Among authors: von melchner h. Nucleic Acids Res. 2008 Nov;36(20):e133. doi: 10.1093/nar/gkn603. Epub 2008 Sep 23. Nucleic Acids Res. 2008. PMID: 18812397 Free PMC article.
CRISPR/Cas9-mediated generic protein tagging in mammalian cells.
Thöne FMB, Kurrle NS, von Melchner H, Schnütgen F. Thöne FMB, et al. Among authors: von melchner h. Methods. 2019 Jul 15;164-165:59-66. doi: 10.1016/j.ymeth.2019.02.018. Epub 2019 Feb 22. Methods. 2019. PMID: 30797903
85 results