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Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Steubler V, Erdinger S, Back MK, Ludewig S, Fässler D, Richter M, Han K, Slomianka L, Amrein I, von Engelhardt J, Wolfer DP, Korte M, Müller UC. Steubler V, et al. Among authors: von engelhardt j. EMBO J. 2021 Jun 15;40(12):e107471. doi: 10.15252/embj.2020107471. Epub 2021 May 19. EMBO J. 2021. PMID: 34008862 Free PMC article.
The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner.
Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D'Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodóvar C. Luck R, et al. Among authors: von engelhardt j. Cell Rep. 2021 Aug 17;36(7):109522. doi: 10.1016/j.celrep.2021.109522. Cell Rep. 2021. PMID: 34407407 Free PMC article.
APPsα Rescues Tau-Induced Synaptic Pathology.
Bold CS, Baltissen D, Ludewig S, Back MK, Just J, Kilian L, Erdinger S, Banicevic M, Rehra L, Almouhanna F, Nigri M, Wolfer DP, Spilger R, Rohr K, Kann O, Buchholz CJ, von Engelhardt J, Korte M, Müller UC. Bold CS, et al. Among authors: von engelhardt j. J Neurosci. 2022 Jul 20;42(29):5782-5802. doi: 10.1523/JNEUROSCI.2200-21.2022. Epub 2022 Jun 6. J Neurosci. 2022. PMID: 35667850 Free PMC article.
Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner.
Vasistha NA, Pardo-Navarro M, Gasthaus J, Weijers D, Müller MK, García-González D, Malwade S, Korshunova I, Pfisterer U, von Engelhardt J, Hougaard KS, Khodosevich K. Vasistha NA, et al. Among authors: von engelhardt j. Mol Psychiatry. 2020 Oct;25(10):2313-2329. doi: 10.1038/s41380-019-0539-5. Epub 2019 Oct 8. Mol Psychiatry. 2020. PMID: 31595033 Free PMC article.
47 results