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Structural basis of odorant recognition by a human odorant receptor.
Billesbølle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A. Billesbølle CB, et al. Among authors: van der velden wjc. Nature. 2023 Mar;615(7953):742-749. doi: 10.1038/s41586-023-05798-y. Epub 2023 Mar 15. Nature. 2023. PMID: 36922591 Free PMC article.
Novel agonist and antagonist radioligands for the GLP-2 receptor. Useful tools for studies of basic GLP-2 receptor pharmacology.
Gadgaard S, van der Velden WJC, Schiellerup SP, Hunt JE, Gabe MBN, Windeløv JA, Boer GA, Kissow H, Ørskov C, Holst JJ, Hartmann B, Rosenkilde MM. Gadgaard S, et al. Among authors: van der velden wjc. Br J Pharmacol. 2022 May;179(9):1998-2015. doi: 10.1111/bph.15766. Epub 2022 Jan 11. Br J Pharmacol. 2022. PMID: 34855984 Free PMC article.
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, Capozzi ME, van der Velden WJ, Stutsman C, Cardona GR, Urva S, Emmerson PJ, Holst JJ, D'Alessio DA, Coghlan MP, Rosenkilde MM, Campbell JE, Sloop KW. Willard FS, et al. JCI Insight. 2020 Sep 3;5(17):e140532. doi: 10.1172/jci.insight.140532. JCI Insight. 2020. PMID: 32730231 Free PMC article.
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system.
Gabe MBN, van der Velden WJC, Gadgaard S, Smit FX, Hartmann B, Bräuner-Osborne H, Rosenkilde MM. Gabe MBN, et al. Among authors: van der velden wjc. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):122-132. doi: 10.1111/bcpt.13289. Epub 2019 Aug 19. Basic Clin Pharmacol Toxicol. 2020. PMID: 31299132 Free PMC article.
Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor.
Smit FX, van der Velden WJC, Kizilkaya HS, Nørskov A, Lückmann M, Hansen TN, Sparre-Ulrich AH, Qvotrup K, Frimurer TM, Rosenkilde MM. Smit FX, et al. Among authors: van der velden wjc. Structure. 2021 Jul 1;29(7):679-693.e6. doi: 10.1016/j.str.2021.04.001. Epub 2021 Apr 22. Structure. 2021. PMID: 33891864 Free article.
Engineered odorant receptors illuminate structural principles of odor discrimination.
de March CA, Ma N, Billesbølle CB, Tewari J, Del Torrent CL, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H. de March CA, et al. Among authors: van der velden wjc. bioRxiv [Preprint]. 2023 Nov 17:2023.11.16.567230. doi: 10.1101/2023.11.16.567230. bioRxiv. 2023. PMID: 38014344 Free PMC article. Preprint.
18 results