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ATP8B1 is essential for maintaining normal hearing.
Stapelbroek JM, Peters TA, van Beurden DH, Curfs JH, Joosten A, Beynon AJ, van Leeuwen BM, van der Velden LM, Bull L, Oude Elferink RP, van Zanten BA, Klomp LW, Houwen RH. Stapelbroek JM, et al. Among authors: van der velden lm, van leeuwen bm, van beurden dh, van zanten ba. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9709-14. doi: 10.1073/pnas.0807919106. Epub 2009 May 28. Proc Natl Acad Sci U S A. 2009. PMID: 19478059 Free PMC article.
A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells.
Verhulst PM, van der Velden LM, Oorschot V, van Faassen EE, Klumperman J, Houwen RH, Pomorski TG, Holthuis JC, Klomp LW. Verhulst PM, et al. Among authors: van der velden lm. Hepatology. 2010 Jun;51(6):2049-60. doi: 10.1002/hep.23586. Hepatology. 2010. PMID: 20512993
Biochemical and cellular functions of P4 ATPases.
van der Velden LM, van de Graaf SF, Klomp LW. van der Velden LM, et al. Biochem J. 2010 Oct 1;431(1):1-11. doi: 10.1042/BJ20100644. Biochem J. 2010. PMID: 20836764 Review.
HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets.
Omta WA, van Heesbeen RG, Pagliero RJ, van der Velden LM, Lelieveld D, Nellen M, Kramer M, Yeong M, Saeidi AM, Medema RH, Spruit M, Brinkkemper S, Klumperman J, Egan DA. Omta WA, et al. Among authors: van der velden lm. Assay Drug Dev Technol. 2016 Oct;14(8):439-452. doi: 10.1089/adt.2016.726. Epub 2016 Sep 16. Assay Drug Dev Technol. 2016. PMID: 27636821
Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening.
Omta WA, van Heesbeen RG, Shen I, de Nobel J, Robers D, van der Velden LM, Medema RH, Siebes APJM, Feelders AJ, Brinkkemper S, Klumperman JS, Spruit MR, Brinkhuis MJS, Egan DA. Omta WA, et al. Among authors: van der velden lm. SLAS Discov. 2020 Jul;25(6):655-664. doi: 10.1177/2472555220919345. Epub 2020 May 13. SLAS Discov. 2020. PMID: 32400262 Free article.
Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis.
van der Velden LM, Maas P, van Amersfoort M, Timmermans-Sprang EPM, Mensinga A, van der Vaart E, Malergue F, Viëtor H, Derksen PWB, Klumperman J, van Agthoven A, Egan DA, Mol JA, Strous GJ. van der Velden LM, et al. Front Endocrinol (Lausanne). 2022 Jul 28;13:926210. doi: 10.3389/fendo.2022.926210. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35966052 Free PMC article.
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