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Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.
Buikema JW, Lee S, Goodyer WR, Maas RG, Chirikian O, Li G, Miao Y, Paige SL, Lee D, Wu H, Paik DT, Rhee S, Tian L, Galdos FX, Puluca N, Beyersdorf B, Hu J, Beck A, Venkamatran S, Swami S, Wijnker P, Schuldt M, Dorsch LM, van Mil A, Red-Horse K, Wu JY, Geisen C, Hesse M, Serpooshan V, Jovinge S, Fleischmann BK, Doevendans PA, van der Velden J, Garcia KC, Wu JC, Sluijter JPG, Wu SM. Buikema JW, et al. Among authors: van mil a, van der velden j. Cell Stem Cell. 2020 Jul 2;27(1):50-63.e5. doi: 10.1016/j.stem.2020.06.001. Cell Stem Cell. 2020. PMID: 32619518 Free PMC article.
Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium.
Wijnker PJ, Boknik P, Gergs U, Müller FU, Neumann J, dos Remedios C, Schmitz W, Sindermann JR, Stienen GJ, van der Velden J, Kirchhefer U. Wijnker PJ, et al. Among authors: van der velden j. J Muscle Res Cell Motil. 2011 Nov;32(3):221-33. doi: 10.1007/s10974-011-9261-x. Epub 2011 Sep 30. J Muscle Res Cell Motil. 2011. PMID: 21959857 Free PMC article.
Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes.
Wijnker PJ, Foster DB, Tsao AL, Frazier AH, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J. Wijnker PJ, et al. Among authors: van der velden j. Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H260-8. doi: 10.1152/ajpheart.00498.2012. Epub 2012 Nov 9. Am J Physiol Heart Circ Physiol. 2013. PMID: 23144315 Free PMC article.
PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.
Kooij V, Zhang P, Piersma SR, Sequeira V, Boontje NM, Wijnker PJ, Jiménez CR, Jaquet KE, dos Remedios C, Murphy AM, Van Eyk JE, van der Velden J, Stienen GJ. Kooij V, et al. Among authors: van eyk je, van der velden j. PLoS One. 2013 Oct 7;8(10):e74847. doi: 10.1371/journal.pone.0074847. eCollection 2013. PLoS One. 2013. PMID: 24116014 Free PMC article.
Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.
Wijnker PJ, Sequeira V, Foster DB, Li Y, Dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J. Wijnker PJ, et al. Among authors: van der velden j. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1171-81. doi: 10.1152/ajpheart.00580.2013. Epub 2014 Feb 28. Am J Physiol Heart Circ Physiol. 2014. PMID: 24585778 Free PMC article.
Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.
Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J. Wijnker PJ, et al. Among authors: van der velden j. Arch Biochem Biophys. 2014 Jul 15;554:11-21. doi: 10.1016/j.abb.2014.04.017. Epub 2014 May 9. Arch Biochem Biophys. 2014. PMID: 24814372 Free PMC article.
A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.
Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J. Wijnker PJ, et al. Among authors: van eyk je, van der velden j. J Mol Cell Cardiol. 2015 May;82:93-103. doi: 10.1016/j.yjmcc.2015.03.006. Epub 2015 Mar 11. J Mol Cell Cardiol. 2015. PMID: 25771144 Free PMC article.
Genotype-specific pathogenic effects in human dilated cardiomyopathy.
Bollen IAE, Schuldt M, Harakalova M, Vink A, Asselbergs FW, Pinto JR, Krüger M, Kuster DWD, van der Velden J. Bollen IAE, et al. Among authors: van der velden j. J Physiol. 2017 Jul 15;595(14):4677-4693. doi: 10.1113/JP274145. Epub 2017 Jun 1. J Physiol. 2017. PMID: 28436080 Free PMC article.
609 results