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ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol.
Kotsaki A, Pickkers P, Bauer M, Calandra T, Lupse M, Wiersinga WJ, Meylan S, Bloos F, van der Poll T, Slim MA, van Mourik N, Müller MCA, van Vught L, Vlaar APJ, de Nooijer A, Bakkerus L, Weis S, Antonakos N, Netea MG, Giamarellos-Bourboulis EJ. Kotsaki A, et al. Among authors: van mourik n, van der poll t, van vught l. BMJ Open. 2022 Dec 20;12(12):e067251. doi: 10.1136/bmjopen-2022-067251. BMJ Open. 2022. PMID: 36600424 Free PMC article.
Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19.
Saris A, Reijnders TDY, Nossent EJ, Schuurman AR, Verhoeff J, Asten SV, Bontkes H, Blok S, Duitman J, Bogaard HJ, Heunks L, Lutter R, van der Poll T, Garcia Vallejo JJ; ArtDECO consortium and the Amsterdam UMC COVID study group. Saris A, et al. Among authors: van der poll t. Thorax. 2021 Oct;76(10):1010-1019. doi: 10.1136/thoraxjnl-2020-216256. Epub 2021 Apr 12. Thorax. 2021. PMID: 33846275 Free PMC article.
Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the  phase 2 PANAMO trial.
Lim EHT, Vlaar APJ, Bos LDJ, van Vught LA, Boer AMT, Dujardin RWG, Habel M, Xu Z, Brouwer MC, van de Beek D, de Bruin S; Amsterdam UMC COVID-19 Biobank Investigators. Lim EHT, et al. Respir Res. 2022 Dec 24;23(1):375. doi: 10.1186/s12931-022-02278-1. Respir Res. 2022. PMID: 36566174 Free PMC article. Clinical Trial.
Artificial Intelligence for Early Sepsis Detection: A Word of Caution.
Schinkel M, van der Poll T, Wiersinga WJ. Schinkel M, et al. Among authors: van der poll t. Am J Respir Crit Care Med. 2023 Apr 1;207(7):853-854. doi: 10.1164/rccm.202212-2284VP. Am J Respir Crit Care Med. 2023. PMID: 36724366 Free PMC article. No abstract available.
Embracing complexity in sepsis.
Schuurman AR, Sloot PMA, Wiersinga WJ, van der Poll T. Schuurman AR, et al. Among authors: van der poll t. Crit Care. 2023 Mar 11;27(1):102. doi: 10.1186/s13054-023-04374-0. Crit Care. 2023. PMID: 36906606 Free PMC article. Review.
Age-related changes in plasma biomarkers and their association with mortality in COVID-19.
Michels EHA, Appelman B, de Brabander J, van Amstel RBE, Chouchane O, van Linge CCA, Schuurman AR, Reijnders TDY, Sulzer TAL, Klarenbeek AM, Douma RA; Amsterdam UMC COVID-19 Biobank Study Group; Bos LDJ, Wiersinga WJ, Peters-Sengers H, van der Poll T; Amsterdam UMC COVID-19 Biobank Study Group; van Agtmael M, Algera AG, Appelman B, van Baarle F, Beudel M, Bogaard HJ, Bomers M, Bonta P, Bos L, Botta M, de Brabander J, de Bree G, de Bruin S, Bugiani M, Bulle E, Buis DTP, Chouchane O, Cloherty A, Dijkstra M, Dongelmans DA, Dujardin RWG, Elbers P, Fleuren L, Geerlings S, Geijtenbeek T, Girbes A, Goorhuis B, Grobusch MP, Hagens L, Hamann J, Harris V, Hemke R, Hermans SM, Heunks L, Hollmann M, Horn J, Hovius JW, de Jong HK, de Jong MD, Koning R, Lemkes B, Lim EHT, van Mourik N, Nellen J, Nossent EJ, Olie S, Paulus F, Peters E, Pina-Fuentes DAI, van der Poll T, Preckel B, Prins JM, Raasveld J, Reijnders T, de Rotte MCFJ, Schinkel M, Schultz MJ, Schrauwen FAP, Schuurman A, Schuurmans J, Sigaloff K, Slim MA, Smeele P, Smit M, Stijnis CS, Stilma W, Teunissen C, Thoral P, Tsonas AM, Tuinman PR, van der Valk M, Veelo DP, Volleman C, de V… See abstract for full author list ➔ Michels EHA, et al. Among authors: van agtmael m, van linge cca, van mourik n, van de beek d, van vugt m, van der poll t, van baarle f, van der valk m, van amstel rbe. Eur Respir J. 2023 Jul 7;62(1):2300011. doi: 10.1183/13993003.00011-2023. Print 2023 Jul. Eur Respir J. 2023. PMID: 37080568 Free PMC article.
Persistent alveolar inflammatory response in critically ill patients with COVID-19 is associated with mortality.
de Brabander J, Boers LS, Kullberg RFJ, Zhang S, Nossent EJ, Heunks LMA, Vlaar APJ, Bonta PI, Schultz MJ, van der Poll T, Duitman J, Bos LDJ; ArtDECO consortium; Amsterdam UMC COVID Study group; BASIC consortium; Amsterdam UMC COVID study group. de Brabander J, et al. Among authors: van der poll t. Thorax. 2023 Sep;78(9):912-921. doi: 10.1136/thorax-2023-219989. Epub 2023 May 4. Thorax. 2023. PMID: 37142421
Thrombocytopenia is associated with a dysregulated host response in severe COVID-19.
Appelman B, Michels EHA, de Brabander J, Peters-Sengers H, van Amstel RBE, Noordzij SM, Klarenbeek AM, van Linge CCA, Chouchane O, Schuurman AR, Reijnders TDY, Douma RA, Bos LDJ; Amsterdam UMC COVID-19 Biobank study group; CovidPredict study group; Wiersinga WJ, van der Poll T. Appelman B, et al. Among authors: van linge cca, van der poll t, van amstel rbe. Thromb Res. 2023 Sep;229:187-197. doi: 10.1016/j.thromres.2023.07.008. Epub 2023 Jul 19. Thromb Res. 2023. PMID: 37541167 Free article.
Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes.
van Amstel RBE, Kennedy JN, Scicluna BP, Bos LDJ, Peters-Sengers H, Butler JM, Cano-Gamez E, Knight JC, Vlaar APJ, Cremer OL, Angus DC, van der Poll T, Seymour CW, van Vught LA; MARS Consortium. van Amstel RBE, et al. Among authors: van vught la, van der poll t. Intensive Care Med. 2023 Nov;49(11):1360-1369. doi: 10.1007/s00134-023-07239-w. Epub 2023 Oct 18. Intensive Care Med. 2023. PMID: 37851064 Free PMC article.
Non-conventional immunomodulation in the management of sepsis.
Slim MA, Turgman O, van Vught LA, van der Poll T, Wiersinga WJ. Slim MA, et al. Among authors: van vught la, van der poll t. Eur J Intern Med. 2024 Mar;121:9-16. doi: 10.1016/j.ejim.2023.10.032. Epub 2023 Oct 31. Eur J Intern Med. 2024. PMID: 37919123 Free article. Review.
1,053 results