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A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.
Rivaud MR, Jansen JA, Postema PG, Nannenberg EA, Mizusawa Y, van der Nagel R, Wolswinkel R, van der Made I, Marchal GA, Rajamani S, Belardinelli L, van Tintelen JP, Tanck MWT, van der Wal AC, de Bakker JMT, van Rijen HV, Creemers EE, Wilde AAM, van den Berg MP, van Veen TAB, Bezzina CR, Remme CA. Rivaud MR, et al. Among authors: van der nagel r. Eur Heart J. 2018 Aug 14;39(31):2898-2907. doi: 10.1093/eurheartj/ehy247. Eur Heart J. 2018. PMID: 29718149
In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms.
Bierhuizen MF, Boulaksil M, van Stuijvenberg L, van der Nagel R, Jansen AT, Mutsaers NA, Yildirim C, van Veen TA, de Windt LJ, Vos MA, van Rijen HV. Bierhuizen MF, et al. Among authors: van rijen hv, van stuijvenberg l, van der nagel r, van veen ta. J Mol Cell Cardiol. 2008 Sep;45(3):373-84. doi: 10.1016/j.yjmcc.2008.06.011. Epub 2008 Jul 11. J Mol Cell Cardiol. 2008. PMID: 18662696
Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction.
Stein M, van Veen TA, Remme CA, Boulaksil M, Noorman M, van Stuijvenberg L, van der Nagel R, Bezzina CR, Hauer RN, de Bakker JM, van Rijen HV. Stein M, et al. Among authors: van rijen hv, van stuijvenberg l, van der nagel r, van veen ta. Cardiovasc Res. 2009 Jul 1;83(1):52-60. doi: 10.1093/cvr/cvp124. Epub 2009 Apr 22. Cardiovasc Res. 2009. PMID: 19389723
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.
Jansen JA, Noorman M, Musa H, Stein M, de Jong S, van der Nagel R, Hund TJ, Mohler PJ, Vos MA, van Veen TA, de Bakker JM, Delmar M, van Rijen HV. Jansen JA, et al. Among authors: van rijen hv, van der nagel r, van veen ta. Heart Rhythm. 2012 Apr;9(4):600-7. doi: 10.1016/j.hrthm.2011.11.025. Epub 2011 Nov 16. Heart Rhythm. 2012. PMID: 22100711 Free PMC article.
Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity.
Jansen JA, van Veen TA, de Jong S, van der Nagel R, van Stuijvenberg L, Driessen H, Labzowski R, Oefner CM, Bosch AA, Nguyen TQ, Goldschmeding R, Vos MA, de Bakker JM, van Rijen HV. Jansen JA, et al. Among authors: van rijen hv, van stuijvenberg l, van der nagel r, van veen ta. Circ Arrhythm Electrophysiol. 2012 Apr;5(2):380-90. doi: 10.1161/CIRCEP.111.966580. Epub 2012 Feb 24. Circ Arrhythm Electrophysiol. 2012. PMID: 22368123
Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress.
van Opbergen CJM, Noorman M, Pfenniger A, Copier JS, Vermij SH, Li Z, van der Nagel R, Zhang M, de Bakker JMT, Glass AM, Mohler PJ, Taffet SM, Vos MA, van Rijen HVM, Delmar M, van Veen TAB. van Opbergen CJM, et al. Among authors: van der nagel r. Int J Mol Sci. 2019 Aug 21;20(17):4076. doi: 10.3390/ijms20174076. Int J Mol Sci. 2019. PMID: 31438494 Free PMC article.
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Bourgonje VJ, Schoenmakers M, Beekman JD, van der Nagel R, Houtman MJ, Miedema LF, Antoons G, Sipido K, de Windt LJ, van Veen TA, Vos MA. Bourgonje VJ, et al. Among authors: van der nagel r, van veen ta. Heart Rhythm. 2012 Nov;9(11):1875-83. doi: 10.1016/j.hrthm.2012.07.023. Epub 2012 Jul 27. Heart Rhythm. 2012. PMID: 22846339
31 results