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Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RMF. de Lange J, et al. Among authors: van der meulen ih. Nat Commun. 2015 Oct 1;6:8399. doi: 10.1038/ncomms9399. Nat Commun. 2015. PMID: 26423134 Free PMC article.
Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
Oosterhoff D, Pinedo HM, van der Meulen IH, de Graaf M, Sone T, Kruyt FA, van Beusechem VW, Haisma HJ, Gerritsen WR. Oosterhoff D, et al. Among authors: van der meulen ih. Br J Cancer. 2002 Sep 9;87(6):659-64. doi: 10.1038/sj.bjc.6600519. Br J Cancer. 2002. PMID: 12237777 Free PMC article.