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Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
Oros A, Houtman MJ, Neco P, Gomez AM, Rajamani S, Oosterhoff P, Attevelt NJ, Beekman JD, van der Heyden MA, Ver Donck L, Belardinelli L, Richard S, Antoons G, Vos MA; CONTICA investigators. Oros A, et al. Among authors: van der heyden ma. Br J Pharmacol. 2010 Sep;161(1):162-75. doi: 10.1111/j.1476-5381.2010.00883.x. Br J Pharmacol. 2010. PMID: 20718748 Free PMC article.
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA. Nalos L, et al. Among authors: van der nagel r, van veen ta, van der heyden ma. Br J Pharmacol. 2012 Jan;165(2):467-78. doi: 10.1111/j.1476-5381.2011.01558.x. Br J Pharmacol. 2012. PMID: 21718297 Free PMC article.
Cardiac ion channel trafficking defects and drugs.
de Git KC, de Boer TP, Vos MA, van der Heyden MA. de Git KC, et al. Among authors: van der heyden ma. Pharmacol Ther. 2013 Jul;139(1):24-31. doi: 10.1016/j.pharmthera.2013.03.008. Epub 2013 Apr 2. Pharmacol Ther. 2013. PMID: 23558293 Review.
145 results