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Cellular senescence impairs the reversibility of pulmonary arterial hypertension.
van der Feen DE, Bossers GPL, Hagdorn QAJ, Moonen JR, Kurakula K, Szulcek R, Chappell J, Vallania F, Donato M, Kok K, Kohli JS, Petersen AH, van Leusden T, Demaria M, Goumans MTH, De Boer RA, Khatri P, Rabinovitch M, Berger RMF, Bartelds B. van der Feen DE, et al. Sci Transl Med. 2020 Jul 29;12(554):eaaw4974. doi: 10.1126/scitranslmed.aaw4974. Sci Transl Med. 2020. PMID: 32727916 Free PMC article.
Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension.
Van der Feen DE, Kurakula K, Tremblay E, Boucherat O, Bossers GPL, Szulcek R, Bourgeois A, Lampron MC, Habbout K, Martineau S, Paulin R, Kulikowski E, Jahagirdar R, Schalij I, Bogaard HJ, Bartelds B, Provencher S, Berger RMF, Bonnet S, Goumans MJ. Van der Feen DE, et al. Am J Respir Crit Care Med. 2019 Oct 1;200(7):910-920. doi: 10.1164/rccm.201812-2275OC. Am J Respir Crit Care Med. 2019. PMID: 31042405
Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling.
Kurakula K, Hagdorn QAJ, van der Feen DE, Vonk Noordegraaf A, Ten Dijke P, de Boer RA, Bogaard HJ, Goumans MJ, Berger RMF. Kurakula K, et al. Among authors: van der feen de. Angiogenesis. 2022 Feb;25(1):99-112. doi: 10.1007/s10456-021-09812-7. Epub 2021 Aug 11. Angiogenesis. 2022. PMID: 34379232 Free PMC article.
Neuregulin-1 enhances cell-cycle activity, delays cardiac fibrosis, and improves cardiac performance in rat pups with right ventricular pressure load.
Bossers GPL, Günthel M, van der Feen DE, Hagdorn QAJ, Koop AC, van Duijvenboden K, Barnett P, Borgdorff MAJ, Christoffels VM, Silljé HHW, Berger RMF, Bartelds B. Bossers GPL, et al. Among authors: van der feen de. J Thorac Cardiovasc Surg. 2022 Dec;164(6):e493-e510. doi: 10.1016/j.jtcvs.2021.10.045. Epub 2021 Nov 3. J Thorac Cardiovasc Surg. 2022. PMID: 34922752 Free article.
17 results