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Local delivery of low-dose anti-CTLA-4 to the melanoma lymphatic basin leads to systemic Treg reduction and effector T cell activation.
van Pul KM, Notohardjo JCL, Fransen MF, Koster BD, Stam AGM, Chondronasiou D, Lougheed SM, Bakker J, Kandiah V, van den Tol MP, Jooss K, Vuylsteke RJCLM, van den Eertwegh AJM, de Gruijl TD. van Pul KM, et al. Among authors: van den tol mp. Sci Immunol. 2022 Jul 15;7(73):eabn8097. doi: 10.1126/sciimmunol.abn8097. Epub 2022 Jul 15. Sci Immunol. 2022. PMID: 35857579 Clinical Trial.
Selective transduction of dendritic cells in human lymph nodes and superior induction of high-avidity melanoma-reactive cytotoxic T cells by a CD40-targeted adenovirus.
Hangalapura BN, Oosterhoff D, Aggarwal S, Wijnands PG, van de Ven R, Santegoets SJ, van den Tol MP, Hooijberg E, Pereboev A, van den Eertwegh AJ, Curiel DT, Scheper RJ, de Gruijl TD. Hangalapura BN, et al. Among authors: van de ven r, van den tol mp, van den eertwegh aj. J Immunother. 2010 Sep;33(7):706-15. doi: 10.1097/CJI.0b013e3181eccbd4. J Immunother. 2010. PMID: 20664356
4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8+ T cells from melanoma sentinel lymph nodes.
Sluijter BJ, van den Hout MF, Stam AG, Lougheed SM, Suhoski MM, van den Eertwegh AJ, van den Tol MP, van Leeuwen PA, Meijer S, Scheper RJ, June CH, de Gruijl TD, Santegoets SJ. Sluijter BJ, et al. Among authors: van den hout mf, van den tol mp, van den eertwegh aj, van leeuwen pa. Clin Immunol. 2010 Nov;137(2):221-33. doi: 10.1016/j.clim.2010.07.009. Epub 2010 Aug 13. Clin Immunol. 2010. PMID: 20708974
Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation.
van de Ven R, van den Hout MF, Lindenberg JJ, Sluijter BJ, van Leeuwen PA, Lougheed SM, Meijer S, van den Tol MP, Scheper RJ, de Gruijl TD. van de Ven R, et al. Among authors: van den hout mf, van den tol mp, van leeuwen pa. Blood. 2011 Sep 1;118(9):2502-10. doi: 10.1182/blood-2011-03-344838. Epub 2011 Jul 12. Blood. 2011. PMID: 21750314 Free article.
Arming the Melanoma Sentinel Lymph Node through Local Administration of CpG-B and GM-CSF: Recruitment and Activation of BDCA3/CD141(+) Dendritic Cells and Enhanced Cross-Presentation.
Sluijter BJ, van den Hout MF, Koster BD, van Leeuwen PA, Schneiders FL, van de Ven R, Molenkamp BG, Vosslamber S, Verweij CL, van den Tol MP, van den Eertwegh AJ, Scheper RJ, de Gruijl TD. Sluijter BJ, et al. Among authors: van den hout mf, van de ven r, van den tol mp, van den eertwegh aj, van leeuwen pa. Cancer Immunol Res. 2015 May;3(5):495-505. doi: 10.1158/2326-6066.CIR-14-0165. Epub 2015 Jan 29. Cancer Immunol Res. 2015. PMID: 25633713 Clinical Trial.
Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph node.
van den Hout MF, Sluijter BJ, Santegoets SJ, van Leeuwen PA, van den Tol MP, van den Eertwegh AJ, Scheper RJ, de Gruijl TD. van den Hout MF, et al. Among authors: van den tol mp, van den eertwegh aj, van leeuwen pa. Cancer Immunol Immunother. 2016 Apr;65(4):405-15. doi: 10.1007/s00262-016-1811-z. Epub 2016 Mar 2. Cancer Immunol Immunother. 2016. PMID: 26935057 Free PMC article. Clinical Trial.
Melanoma Sequentially Suppresses Different DC Subsets in the Sentinel Lymph Node, Affecting Disease Spread and Recurrence.
van den Hout MFCM, Koster BD, Sluijter BJR, Molenkamp BG, van de Ven R, van den Eertwegh AJM, Scheper RJ, van Leeuwen PAM, van den Tol MP, de Gruijl TD. van den Hout MFCM, et al. Among authors: van den eertwegh ajm, van de ven r, van den tol mp, van leeuwen pam. Cancer Immunol Res. 2017 Nov;5(11):969-977. doi: 10.1158/2326-6066.CIR-17-0110. Epub 2017 Sep 21. Cancer Immunol Res. 2017. PMID: 28935649
Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation.
Scheffer HJ, Stam AGM, Geboers B, Vroomen LGPH, Ruarus A, de Bruijn B, van den Tol MP, Kazemier G, Meijerink MR, de Gruijl TD. Scheffer HJ, et al. Among authors: van den tol mp. Oncoimmunology. 2019 Aug 28;8(11):1652532. doi: 10.1080/2162402X.2019.1652532. eCollection 2019. Oncoimmunology. 2019. PMID: 31646081 Free PMC article.
86 results