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Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation.
Carroll C, Manaprasertsak A, Boffelli Castro A, van den Bos H, Spierings DCJ, Wardenaar R, Bukkuri A, Engström N, Baratchart E, Yang M, Biloglav A, Cornwallis CK, Johansson B, Hagerling C, Arsenian-Henriksson M, Paulsson K, Amend SR, Mohlin S, Foijer F, McIntyre A, Pienta KJ, Hammarlund EU. Carroll C, et al. Among authors: van den bos h. Cancer Res Commun. 2024 Mar 7;4(3):691-705. doi: 10.1158/2767-9764.CRC-23-0396. Cancer Res Commun. 2024. PMID: 38385626 Free PMC article.
Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia.
Woodward EL, Yang M, Moura-Castro LH, van den Bos H, Gunnarsson R, Olsson-Arvidsson L, Spierings DCJ, Castor A, Duployez N, Zaliova M, Zuna J, Johansson B, Foijer F, Paulsson K. Woodward EL, et al. Among authors: van den bos h. Nat Commun. 2023 Mar 25;14(1):1658. doi: 10.1038/s41467-023-37356-5. Nat Commun. 2023. PMID: 36966135 Free PMC article.
Single-cell sequencing to quantify genomic integrity in cancer.
van den Bos H, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F. van den Bos H, et al. Int J Biochem Cell Biol. 2018 Jan;94:146-150. doi: 10.1016/j.biocel.2017.09.016. Epub 2017 Sep 23. Int J Biochem Cell Biol. 2018. PMID: 28951245 Review.
Loss of NF2 defines a genetic subgroup of non-FOS-rearranged osteoblastoma.
Saba KH, Cornmark L, Hofvander J, Magnusson L, Nilsson J, van den Bos H, Spierings DC, Foijer F, Staaf J, Brosjö O, Sumathi VP, Lam SW, Szuhai K, Bovée JV, Kovac M, Baumhoer D, Styring E, Nord KH. Saba KH, et al. Among authors: van den bos h. J Pathol Clin Res. 2020 Oct;6(4):231-237. doi: 10.1002/cjp2.172. Epub 2020 Jun 16. J Pathol Clin Res. 2020. PMID: 32542935 Free PMC article.
Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance.
Mañas A, Aaltonen K, Andersson N, Hansson K, Adamska A, Seger A, Yasui H, van den Bos H, Radke K, Esfandyari J, Bhave MS, Karlsson J, Spierings D, Foijer F, Gisselsson D, Bexell D. Mañas A, et al. Among authors: van den bos h. Sci Adv. 2022 Oct 28;8(43):eabq4617. doi: 10.1126/sciadv.abq4617. Epub 2022 Oct 28. Sci Adv. 2022. PMID: 36306349 Free PMC article.
Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival.
Tamminga M, Andree KC, van den Bos H, Hiltermann TJN, Mentink A, Spierings DCJ, Lansdorp P, Timens W, Schuuring E, Terstappen LWMM, Groen HJM. Tamminga M, et al. Among authors: van den bos h. Br J Cancer. 2022 Feb;126(3):409-418. doi: 10.1038/s41416-021-01634-0. Epub 2021 Nov 30. Br J Cancer. 2022. PMID: 34848855 Free PMC article.
Quantification of Aneuploidy in Mammalian Systems.
van den Bos H, Bakker B, Taudt A, Guryev V, Colomé-Tatché M, Lansdorp PM, Foijer F, Spierings DCJ. van den Bos H, et al. Methods Mol Biol. 2019;1896:159-190. doi: 10.1007/978-1-4939-8931-7_15. Methods Mol Biol. 2019. PMID: 30474848
Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways.
Spain L, Coulton A, Lobon I, Rowan A, Schnidrig D, Shepherd STC, Shum B, Byrne F, Goicoechea M, Piperni E, Au L, Edmonds K, Carlyle E, Hunter N, Renn A, Messiou C, Hughes P, Nobbs J, Foijer F, van den Bos H, Wardenaar R, Spierings DCJ, Spencer C, Schmitt AM, Tippu Z, Lingard K, Grostate L, Peat K, Kelly K, Sarker S, Vaughan S, Mangwende M, Terry L, Kelly D, Biano J, Murra A, Korteweg J, Lewis C, O'Flaherty M, Cattin AL, Emmerich M, Gerard CL, Pallikonda HA, Lynch J, Mason R, Rogiers A, Xu H, Huebner A, McGranahan N, Al Bakir M, Murai J, Naceur-Lombardelli C, Borg E, Mitchison M, Moore DA, Falzon M, Proctor I, Stamp GWH, Nye EL, Young K, Furness AJS, Pickering L, Stewart R, Mahadeva U, Green A, Larkin J, Litchfield K, Swanton C, Jamal-Hanjani M; PEACE Consortium; Turajlic S. Spain L, et al. Among authors: van den bos h. Cancer Discov. 2023 Jun 2;13(6):1364-1385. doi: 10.1158/2159-8290.CD-22-1427. Cancer Discov. 2023. PMID: 36977461 Free PMC article.
Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway.
Saba KH, Difilippo V, Kovac M, Cornmark L, Magnusson L, Nilsson J, van den Bos H, Spierings DC, Bidgoli M, Jonson T, Sumathi VP, Brosjö O, Staaf J, Foijer F, Styring E, Nathrath M, Baumhoer D, Nord KH. Saba KH, et al. Among authors: van den bos h. J Pathol. 2024 Feb;262(2):147-160. doi: 10.1002/path.6219. Epub 2023 Nov 27. J Pathol. 2024. PMID: 38010733
23 results