Differential functional selectivity and downstream signaling bias of ghrelin receptor antagonists and inverse agonists.
Ramirez VT, van Oeffelen WEPA, Torres-Fuentes C, Chruścicka B, Druelle C, Golubeva AV, van de Wouw M, Dinan TG, Cryan JF, Schellekens H.
Ramirez VT, et al. Among authors: van oeffelen wepa, van de wouw m.
FASEB J. 2019 Jan;33(1):518-531. doi: 10.1096/fj.201800655R. Epub 2018 Jul 18.
FASEB J. 2019.
PMID: 30020830
Considering the limited success in the clinical development of GHSR-1a-targeted drugs so far, these findings provide a novel insight into the pharmacologic characteristics of GHSR-1a ligands and their signaling bias, which has important implications in the design of novel, more s …
Considering the limited success in the clinical development of GHSR-1a-targeted drugs so far, these findings provide a novel insight into th …