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LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Mov Disord. 2023 Mar;38(3):386-398. doi: 10.1002/mds.29297. Epub 2023 Feb 18.
Mov Disord. 2023.
PMID: 36807624
Clinical Trial.
First-in-human study of the pharmacokinetics and antiviral activity of IDX375, a novel nonnucleoside hepatitis C virus polymerase inhibitor.
de Bruijne J, van de Wetering de Rooij J, van Vliet AA, Zhou XJ, Temam MF, Molles J, Chen J, Pietropaolo K, Sullivan-Bólyai JZ, Mayers D, Reesink HW.
de Bruijne J, et al. Among authors: van de wetering de rooij j.
Antimicrob Agents Chemother. 2012 Aug;56(8):4525-8. doi: 10.1128/AAC.00451-12. Epub 2012 Jun 4.
Antimicrob Agents Chemother. 2012.
PMID: 22664976
Free PMC article.
Clinical Trial.
Item in Clipboard
Randomized, double-blind, placebo-controlled, dose-escalating phase I, healthy subjects study of intravenous OPN-305, a humanized anti-TLR2 antibody.
Reilly M, Miller RM, Thomson MH, Patris V, Ryle P, McLoughlin L, Mutch P, Gilboy P, Miller C, Broekema M, Keogh B, McCormack W, van de Wetering de Rooij J.
Reilly M, et al. Among authors: van de wetering de rooij j.
Clin Pharmacol Ther. 2013 Nov;94(5):593-600. doi: 10.1038/clpt.2013.150. Epub 2013 Jul 23.
Clin Pharmacol Ther. 2013.
PMID: 23880971
Free PMC article.
Clinical Trial.
Item in Clipboard
Safety and antiviral activity of JTK-652: a novel HCV infection inhibitor.
de Bruijne J, Bergmann JF, Weegink CJ, van Nieuwkerk CM, de Knegt RJ, Komoda Y, van de Wetering de Rooij JJ, van Vliet A, Jansen PL, Molenkamp R, Schinkel J, Reesink H, Janssen HL.
de Bruijne J, et al. Among authors: van de wetering de rooij jj.
Antivir Ther. 2010;15(5):765-73. doi: 10.3851/IMP1606.
Antivir Ther. 2010.
PMID: 20710058
Clinical Trial.
Item in Clipboard
Pharmacokinetics and antiviral activity of PHX1766, a novel HCV protease inhibitor, using an accelerated Phase I study design.
Hotho DM, de Bruijne J, O'Farrell AM, Boyea T, Li J, Bracken M, Li X, Campbell D, Guler HP, Weegink CJ, Schinkel J, Molenkamp R, van de Wetering de Rooij J, van Vliet A, Janssen HL, de Knegt RJ, Reesink HW.
Hotho DM, et al. Among authors: van de wetering de rooij j.
Antivir Ther. 2012;17(2):365-75. doi: 10.3851/IMP1989. Epub 2011 Nov 30.
Antivir Ther. 2012.
PMID: 22293533
Clinical Trial.
Item in Clipboard
Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.
Bain G, King CD, Schaab K, Rewolinski M, Norris V, Ambery C, Bentley J, Yamada M, Santini AM, van de Wetering de Rooij J, Stock N, Zunic J, Hutchinson JH, Evans JF.
Bain G, et al. Among authors: van de wetering de rooij j.
Br J Clin Pharmacol. 2013 Mar;75(3):779-90. doi: 10.1111/j.1365-2125.2012.04386.x.
Br J Clin Pharmacol. 2013.
PMID: 22803688
Free PMC article.
Clinical Trial.
Item in Clipboard
Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7.
Boonstra A, Liu BS, Groothuismink ZM, Bergmann JF, de Bruijne J, Hotho DM, Hansen BE, van Vliet AA, van de Wetering de Rooij J, Fletcher SP, Bauman LA, Rahimy M, Appleman JR, Freddo JL, Reesink HW, de Knegt RJ, Janssen HL.
Boonstra A, et al. Among authors: van de wetering de rooij j.
Antivir Ther. 2012;17(4):657-67. doi: 10.3851/IMP2023. Epub 2011 Dec 19.
Antivir Ther. 2012.
PMID: 22301364
Item in Clipboard
Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study.
Reesink HW, Zeuzem S, Weegink CJ, Forestier N, van Vliet A, van de Wetering de Rooij J, McNair L, Purdy S, Kauffman R, Alam J, Jansen PL.
Reesink HW, et al. Among authors: van de wetering de rooij j.
Gastroenterology. 2006 Oct;131(4):997-1002. doi: 10.1053/j.gastro.2006.07.013.
Gastroenterology. 2006.
PMID: 17030169
Clinical Trial.
Item in Clipboard
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