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An exercise-inducible metabolite that suppresses feeding and obesity.
Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung AS, Lyu X, Zushin PH, Jansen RS, Michael B, Loh KY, Yang AC, Carl CS, Voldstedlund CT, Wei W, Terrell SM, Moeller BC, Arthur RM, Wallis GA, van de Wetering K, Stahl A, Kiens B, Richter EA, Banik SM, Snyder MP, Xu Y, Long JZ. Li VL, et al. Among authors: van de wetering k. Nature. 2022 Jun;606(7915):785-790. doi: 10.1038/s41586-022-04828-5. Epub 2022 Jun 15. Nature. 2022. PMID: 35705806 Free PMC article.
MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum.
Rijpma SR, van der Velden M, Bilos A, Jansen RS, Mahakena S, Russel FG, Sauerwein RW, van de Wetering K, Koenderink JB. Rijpma SR, et al. Among authors: van der velden m, van de wetering k. FEBS Lett. 2016 Feb;590(4):482-92. doi: 10.1002/1873-3468.12079. Epub 2016 Feb 17. FEBS Lett. 2016. PMID: 26900081 Free article.
A new enzymatic assay to quantify inorganic pyrophosphate in plasma.
Lundkvist S, Niaziorimi F, Szeri F, Caffet M, Terry SF, Johansson G, Jansen RS, van de Wetering K. Lundkvist S, et al. Among authors: van de wetering k. Anal Bioanal Chem. 2023 Jan;415(3):481-492. doi: 10.1007/s00216-022-04430-8. Epub 2022 Nov 19. Anal Bioanal Chem. 2023. PMID: 36400967 Free PMC article.
ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release.
Jansen RS, Küçükosmanoglu A, de Haas M, Sapthu S, Otero JA, Hegman IE, Bergen AA, Gorgels TG, Borst P, van de Wetering K. Jansen RS, et al. Among authors: de haas m, van de wetering k. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20206-11. doi: 10.1073/pnas.1319582110. Epub 2013 Nov 25. Proc Natl Acad Sci U S A. 2013. PMID: 24277820 Free PMC article.
N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.
Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, Altelaar M, IJlst L, Wanders RJ, Borst P, van de Wetering K. Jansen RS, et al. Among authors: van de wetering k. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601-6. doi: 10.1073/pnas.1424638112. Epub 2015 May 11. Proc Natl Acad Sci U S A. 2015. PMID: 25964343 Free PMC article.
ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report.
Jansen RS, Duijst S, Mahakena S, Sommer D, Szeri F, Váradi A, Plomp A, Bergen AA, Oude Elferink RP, Borst P, van de Wetering K. Jansen RS, et al. Among authors: van de wetering k. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1985-9. doi: 10.1161/ATVBAHA.114.304017. Epub 2014 Jun 26. Arterioscler Thromb Vasc Biol. 2014. PMID: 24969777 Free PMC article.
Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.
Vlaming ML, Pala Z, van Esch A, Wagenaar E, van Tellingen O, de Waart DR, Oude Elferink RP, van de Wetering K, Schinkel AH. Vlaming ML, et al. Among authors: de waart dr, van tellingen o, van esch a, van de wetering k. Clin Cancer Res. 2008 Dec 15;14(24):8152-60. doi: 10.1158/1078-0432.CCR-08-1609. Clin Cancer Res. 2008. PMID: 19088030
57 results