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Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice.
Slijepcevic D, Roscam Abbing RLP, Katafuchi T, Blank A, Donkers JM, van Hoppe S, de Waart DR, Tolenaars D, van der Meer JHM, Wildenberg M, Beuers U, Oude Elferink RPJ, Schinkel AH, van de Graaf SFJ. Slijepcevic D, et al. Among authors: de waart dr, van der meer jhm, van hoppe s, van de graaf sfj. Hepatology. 2017 Nov;66(5):1631-1643. doi: 10.1002/hep.29251. Epub 2017 Sep 29. Hepatology. 2017. PMID: 28498614 Free PMC article.
Developments in bile salt based therapies: A critical overview.
Donkers JM, Roscam Abbing RLP, van de Graaf SFJ. Donkers JM, et al. Among authors: van de graaf sfj. Biochem Pharmacol. 2019 Mar;161:1-13. doi: 10.1016/j.bcp.2018.12.018. Epub 2018 Dec 22. Biochem Pharmacol. 2019. PMID: 30582898 Free article. Review.
Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice.
Roscam Abbing RLP, Slijepcevic D, Donkers JM, Havinga R, Duijst S, Paulusma CC, Kuiper J, Kuipers F, Groen AK, Oude Elferink RPJ, van de Graaf SFJ. Roscam Abbing RLP, et al. Among authors: van de graaf sfj. Hepatology. 2020 Jan;71(1):247-258. doi: 10.1002/hep.30792. Epub 2019 Aug 13. Hepatology. 2020. PMID: 31136002 Free PMC article.
NTCP deficiency in mice protects against obesity and hepatosteatosis.
Donkers JM, Kooijman S, Slijepcevic D, Kunst RF, Roscam Abbing RL, Haazen L, de Waart DR, Levels JH, Schoonjans K, Rensen PC, Oude Elferink RP, van de Graaf SF. Donkers JM, et al. JCI Insight. 2019 Jun 25;5(14):e127197. doi: 10.1172/jci.insight.127197. JCI Insight. 2019. PMID: 31237863 Free PMC article.
Mechanistic insights into the inhibition of NTCP by myrcludex B.
Donkers JM, Appelman MD, van de Graaf SFJ. Donkers JM, et al. Among authors: van de graaf sfj. JHEP Rep. 2019 Aug 1;1(4):278-285. doi: 10.1016/j.jhepr.2019.07.006. eCollection 2019 Oct. JHEP Rep. 2019. PMID: 32039379 Free PMC article.
Inhibition of Hepatic Bile Acid Uptake by Myrcludex B Promotes Glucagon-Like Peptide-1 Release and Reduces Obesity.
Donkers JM, Roscam Abbing RLP, van Weeghel M, Levels JHM, Boelen A, Schinkel AH, Oude Elferink RPJ, van de Graaf SFJ. Donkers JM, et al. Among authors: van weeghel m, van de graaf sfj. Cell Mol Gastroenterol Hepatol. 2020;10(3):451-466. doi: 10.1016/j.jcmgh.2020.04.009. Epub 2020 Apr 21. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32330730 Free PMC article.
Intestinal Bacteremia After Liver Transplantation Is a Risk Factor for Recurrence of Primary Sclerosing Cholangitis.
Mammadov RA, Selten JW, Roest HP, Verhoeven CJ, Maroni L, Bril SI, Tolenaars D, Gadjradj PS, van de Graaf SFJ, Oude Elferink RPJ, Kwekkeboom J, Metselaar HJ, Peppelenbosch MP, Beuers U, IJzermans JNM, van der Laan LJW. Mammadov RA, et al. Among authors: van de graaf sfj. Transplantation. 2023 Aug 1;107(8):1764-1775. doi: 10.1097/TP.0000000000004563. Epub 2023 Mar 29. Transplantation. 2023. PMID: 36978227
92 results