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Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy.
Chancellor DR, Davies KE, De Moor O, Dorgan CR, Johnson PD, Lambert AG, Lawrence D, Lecci C, Maillol C, Middleton PJ, Nugent G, Poignant SD, Potter AC, Price PD, Pye RJ, Storer R, Tinsley JM, van Well R, Vickers R, Vile J, Wilkes FJ, Wilson FX, Wren SP, Wynne GM. Chancellor DR, et al. Among authors: van well r. J Med Chem. 2011 May 12;54(9):3241-50. doi: 10.1021/jm200135z. Epub 2011 Apr 15. J Med Chem. 2011. PMID: 21456623
Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-hydroxy-meth-yl-5-methyl-octa-hydro-indolizine-1,2-diol hydro-bromide].
Thompson AL, Michalik A, Nash RJ, Wilson FX, van Well R, Johnson P, Fleet GW, Yu CY, Hu XG, Cooper RI, Watkin DJ. Thompson AL, et al. Among authors: van well r. Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 28;65(Pt 11):o2904-5. doi: 10.1107/S1600536809043827. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21578486 Free PMC article.
A practical synthesis of gramicidin s and sugar amino Acid containing analogues.
Grotenbreg GM, Kronemeijer M, Timmer MS, El Oualid F, van Well RM, Verdoes M, Spalburg E, van Hooft PA, de Neeling AJ, Noort D, van Boom JH, van der Marel GA, Overkleeft HS, Overhand M. Grotenbreg GM, et al. Among authors: van well rm. J Org Chem. 2004 Nov 12;69(23):7851-9. doi: 10.1021/jo0487449. J Org Chem. 2004. PMID: 15527261
Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure.
van Well RM, Marinelli L, Altona C, Erkelens K, Siegal G, van Raaij M, Llamas-Saiz AL, Kessler H, Novellino E, Lavecchia A, van Boom JH, Overhand M. van Well RM, et al. J Am Chem Soc. 2003 Sep 10;125(36):10822-9. doi: 10.1021/ja035461+. J Am Chem Soc. 2003. PMID: 12952461
11 results