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Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.
Verhaegh W, van Ooijen H, Inda MA, Hatzis P, Versteeg R, Smid M, Martens J, Foekens J, van de Wiel P, Clevers H, van de Stolpe A. Verhaegh W, et al. Among authors: van ooijen h, van de wiel p, van de stolpe a. Cancer Res. 2014 Jun 1;74(11):2936-45. doi: 10.1158/0008-5472.CAN-13-2515. Epub 2014 Apr 2. Cancer Res. 2014. PMID: 24695361 Free article.
Assessment of Functional Phosphatidylinositol 3-Kinase Pathway Activity in Cancer Tissue Using Forkhead Box-O Target Gene Expression in a Knowledge-Based Computational Model.
van Ooijen H, Hornsveld M, Dam-de Veen C, Velter R, Dou M, Verhaegh W, Burgering B, van de Stolpe A. van Ooijen H, et al. Among authors: van de stolpe a. Am J Pathol. 2018 Sep;188(9):1956-1972. doi: 10.1016/j.ajpath.2018.05.020. Epub 2018 Jul 6. Am J Pathol. 2018. PMID: 30030980 Free article.
FOXO transcriptional activity is associated with response to chemoradiation in EAC.
Creemers A, van der Zalm AP, van de Stolpe A, Holtzer L, Stoffels M, Hooijer GKJ, Ebbing EA, van Ooijen H, van Brussel AGC, Aussems-Custers EMG, van Berge Henegouwen MI, Hulshof MCCM, Bergman JJGHM, Meijer SL, Bijlsma MF, van Laarhoven HWM. Creemers A, et al. Among authors: van ooijen h. J Transl Med. 2022 Apr 25;20(1):183. doi: 10.1186/s12967-022-03376-w. J Transl Med. 2022. PMID: 35468793 Free PMC article.
Molecular pixelation: spatial proteomics of single cells by sequencing.
Karlsson F, Kallas T, Thiagarajan D, Karlsson M, Schweitzer M, Navarro JF, Leijonancker L, Geny S, Pettersson E, Rhomberg-Kauert J, Larsson L, van Ooijen H, Petkov S, González-Granillo M, Bunz J, Dahlberg J, Simonetti M, Sathe P, Brodin P, Barrio AM, Fredriksson S. Karlsson F, et al. Among authors: van ooijen h. Nat Methods. 2024 May 8. doi: 10.1038/s41592-024-02268-9. Online ahead of print. Nat Methods. 2024. PMID: 38720062
Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells.
Hammer Q, Perica K, van Ooijen H, Mbofung R, Momayyezi P, Varady E, Martin KE, Pan Y, Jelcic M, Groff B, Abujarour R, Krokeide S, Lee T, Williams A, Goodridge JP, Valamehr B, Önfelt B, Sadelain M, Malmberg KJ. Hammer Q, et al. Among authors: van ooijen h. bioRxiv [Preprint]. 2023 Oct 9:2023.10.09.557143. doi: 10.1101/2023.10.09.557143. bioRxiv. 2023. PMID: 37873468 Free PMC article. Preprint.
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