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High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1.
Steins A, van Mackelenbergh MG, van der Zalm AP, Klaassen R, Serrels B, Goris SG, Kocher HM, Waasdorp C, de Jong JH, Tekin C, Besselink MG, Busch OR, van de Vijver MJ, Verheij J, Dijk F, van Tienhoven G, Wilmink JW, Medema JP, van Laarhoven HW, Bijlsma MF. Steins A, et al. Among authors: van mackelenbergh mg. EMBO Rep. 2020 May 6;21(5):e48780. doi: 10.15252/embr.201948780. Epub 2020 Mar 16. EMBO Rep. 2020. PMID: 32173982 Free PMC article.
Protein kinase C activation inhibits receptor-evoked inositol trisphosphate formation and induction of cytosolic calcium oscillations by decreasing the affinity-state of the cholecystokinin receptor in pancreatic acinar cells.
Willems PH, Smeets RL, Bosch RR, Garner KM, Van Mackelenbergh MG, De Pont JJ. Willems PH, et al. Among authors: van mackelenbergh mg. Cell Calcium. 1995 Dec;18(6):471-83. doi: 10.1016/0143-4160(95)90010-1. Cell Calcium. 1995. PMID: 8746946
CCK8-evoked Ca2+ mobilization in pancreatic acinar cells. Evidence for a regulatory role of protein kinase C by phosphorylation-dependent inhibition of signaling through the high-affinity CCK receptor.
Willems PH, van Hoof HJ, van Mackelenbergh MG, Hoenderop JG, van Emst-de Vries SE, De Pont JJ. Willems PH, et al. Among authors: van mackelenbergh mg. Ann N Y Acad Sci. 1994 Mar 23;713:343-5. doi: 10.1111/j.1749-6632.1994.tb44087.x. Ann N Y Acad Sci. 1994. PMID: 8185182 No abstract available.