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ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy.
Wielenga MCB, Colak S, Heijmans J, van Lidth de Jeude JF, Rodermond HM, Paton JC, Paton AW, Vermeulen L, Medema JP, van den Brink GR. Wielenga MCB, et al. Among authors: van lidth de jeude jf. Cell Rep. 2015 Oct 20;13(3):489-494. doi: 10.1016/j.celrep.2015.09.016. Epub 2015 Oct 8. Cell Rep. 2015. PMID: 26456824 Free article.
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.
Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M, Ferrante M, Lee AS, Onderwater JJ, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V, van den Brink GR. Heijmans J, et al. Among authors: van lidth de jeude jf. Cell Rep. 2013 Apr 25;3(4):1128-39. doi: 10.1016/j.celrep.2013.02.031. Epub 2013 Mar 28. Cell Rep. 2013. PMID: 23545496 Free article.
Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.
Heijmans J, Wielenga MC, Rosekrans SL, van Lidth de Jeude JF, Roelofs J, Groothuis P, Ederveen A, de Jonge-Muller ES, Biemond I, Hardwick JC, D'Haens G, Hommes DW, Muncan V, van den Brink GR. Heijmans J, et al. Among authors: van lidth de jeude jf. Gut. 2014 Feb;63(2):310-6. doi: 10.1136/gutjnl-2012-304216. Epub 2013 Feb 13. Gut. 2014. PMID: 23408349
Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.
van Lidth de Jeude JF, Spaan CN, Meijer BJ, Smit WL, Soeratram TTD, Wielenga MCB, Westendorp BF, Lee AS, Meisner S, Vermeulen JLM, Wildenberg ME, van den Brink GR, Muncan V, Heijmans J. van Lidth de Jeude JF, et al. Cancer Res. 2018 Nov 1;78(21):6098-6106. doi: 10.1158/0008-5472.CAN-17-3600. Epub 2018 Sep 19. Cancer Res. 2018. PMID: 30232220 Free PMC article.