van Koppen CJ - Search Results

1

Effects of 17β-HSD2 inhibition in bones on osteoporosis based on an animal rat model.

Müller ST, Pählig S, Merabet A, Abdelsamie AS, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW, Zierau O, Vollmer G. Müller ST, et al. Among authors: van koppen cj. J Steroid Biochem Mol Biol. 2019 Sep;192:105405. doi: 10.1016/j.jsbmb.2019.105405. Epub 2019 Jun 8. J Steroid Biochem Mol Biol. 2019. PMID: 31185280

2

Potent 11β-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing.

Zhu W, Hu Q, Hanke N, van Koppen CJ, Hartmann RW. Zhu W, et al. Among authors: van koppen cj. J Med Chem. 2014 Sep 25;57(18):7811-7. doi: 10.1021/jm501004t. Epub 2014 Sep 8. J Med Chem. 2014. PMID: 25176013

3

Advances in the treatment of chronic wounds: a patent review.

van Koppen CJ, Hartmann RW. van Koppen CJ, et al. Expert Opin Ther Pat. 2015;25(8):931-7. doi: 10.1517/13543776.2015.1045879. Epub 2015 Jun 3. Expert Opin Ther Pat. 2015. PMID: 26039457 Review.

4

17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog.

Gargano EM, Allegretta G, Perspicace E, Carotti A, Van Koppen C, Frotscher M, Marchais-Oberwinkler S, Hartmann RW. Gargano EM, et al. PLoS One. 2015 Jul 31;10(7):e0134754. doi: 10.1371/journal.pone.0134754. eCollection 2015. PLoS One. 2015. PMID: 26230928 Free PMC article.

5

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Hoyt SB, Petrilli W, London C, Liang GB, Tata J, Hu Q, Yin L, van Koppen CJ, Hartmann RW, Struthers M, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Xiong Y. Hoyt SB, et al. Among authors: van koppen cj. ACS Med Chem Lett. 2015 Jul 17;6(8):861-5. doi: 10.1021/acsmedchemlett.5b00048. eCollection 2015 Aug 13. ACS Med Chem Lett. 2015. PMID: 26288685 Free PMC article.

6

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme.

Abdelsamie AS, Bey E, Gargano EM, van Koppen CJ, Empting M, Frotscher M. Abdelsamie AS, et al. Among authors: van koppen cj. Eur J Med Chem. 2015 Oct 20;103:56-68. doi: 10.1016/j.ejmech.2015.08.030. Epub 2015 Aug 18. Eur J Med Chem. 2015. PMID: 26322835

7

Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC₅₀ for a proof-of-principle study.

Abdelsamie AS, van Koppen CJ, Bey E, Salah M, Börger C, Siebenbürger L, Laschke MW, Menger MD, Frotscher M. Abdelsamie AS, et al. Among authors: van koppen cj. Eur J Med Chem. 2017 Feb 15;127:944-957. doi: 10.1016/j.ejmech.2016.11.004. Epub 2016 Nov 4. Eur J Med Chem. 2017. PMID: 27852458

8

First Structure-Activity Relationship of 17β-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.

Braun F, Bertoletti N, Möller G, Adamski J, Steinmetzer T, Salah M, Abdelsamie AS, van Koppen CJ, Heine A, Klebe G, Marchais-Oberwinkler S. Braun F, et al. Among authors: van koppen cj. J Med Chem. 2016 Dec 8;59(23):10719-10737. doi: 10.1021/acs.jmedchem.6b01436. Epub 2016 Nov 18. J Med Chem. 2016. PMID: 27933965

9

Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease.

Emmerich J, van Koppen CJ, Burkhart JL, Hu Q, Siebenbürger L, Boerger C, Scheuer C, Laschke MW, Menger MD, Hartmann RW. Emmerich J, et al. Among authors: van koppen cj. J Med Chem. 2017 Jun 22;60(12):5086-5098. doi: 10.1021/acs.jmedchem.7b00437. Epub 2017 Jun 9. J Med Chem. 2017. PMID: 28570067

10

Accelerated skin wound healing by selective 11β-Hydroxylase (CYP11B1) inhibitors.

Emmerich J, van Koppen CJ, Burkhart JL, Engeli RT, Hu Q, Odermatt A, Hartmann RW. Emmerich J, et al. Among authors: van koppen cj. Eur J Med Chem. 2018 Jan 1;143:591-597. doi: 10.1016/j.ejmech.2017.11.018. Epub 2017 Nov 21. Eur J Med Chem. 2018. PMID: 29207342

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