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Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α1-antitrypsin-derived peptide motif.
Cruz MA, Bohinc D, Andraska EA, Alvikas J, Raghunathan S, Masters NA, van Kleef ND, Bane KL, Hart K, Medrow K, Sun M, Liu H, Haldeman S, Banerjee A, Lessieur EM, Hageman K, Gandhi A, de la Fuente M, Nieman MT, Kern TS, Maas C, de Maat S, Neeves KB, Neal MD, Sen Gupta A, Stavrou EX. Cruz MA, et al. Among authors: van kleef nd. Nat Nanotechnol. 2022 Sep;17(9):1004-1014. doi: 10.1038/s41565-022-01161-w. Epub 2022 Jul 18. Nat Nanotechnol. 2022. PMID: 35851383 Free PMC article.
Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis.
de Maat S, Clark CC, Barendrecht AD, Smits S, van Kleef ND, El Otmani H, Waning M, van Moorsel M, Szardenings M, Delaroque N, Vercruysse K, Urbanus RT, Sebastian S, Lenting PJ, Hagemeyer CE, Renné T, Vanhoorelbeke K, Tersteeg C, Maas C. de Maat S, et al. Among authors: van kleef nd. Blood. 2022 Jan 27;139(4):597-607. doi: 10.1182/blood.2021011776. Blood. 2022. PMID: 34752601 Free article.
Altered fibrin network structure and fibrinolysis in intensive care unit patients with COVID-19, not entirely explaining the increased risk of thrombosis.
de Vries JJ, Visser C, Geers L, Slotman JA, van Kleef ND, Maas C, Bax HI, Miedema JR, van Gorp ECM, Goeijenbier M, van den Akker JPC, Endeman H, Rijken DC, Kruip MJHA, de Maat MPM. de Vries JJ, et al. Among authors: van kleef nd. J Thromb Haemost. 2022 Jun;20(6):1412-1420. doi: 10.1111/jth.15708. Epub 2022 Apr 1. J Thromb Haemost. 2022. PMID: 35316570 Free PMC article.
Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy.
Lischer C, Eberhardt M, Flamann C, Berges J, Güse E, Wessely A, Weich A, Retzlaff J, Dörrie J, Schaft N, Wiesinger M, März J, Schuler-Thurner B, Knorr H, Gupta S, Singh KP, Schuler G, Heppt MV, Koch EAT, van Kleef ND, Freen-van Heeren JJ, Turksma AW, Wolkenhauer O, Hohberger B, Berking C, Bruns H, Vera J. Lischer C, et al. Among authors: van kleef nd. J Immunother Cancer. 2024 May 9;12(5):e008104. doi: 10.1136/jitc-2023-008104. J Immunother Cancer. 2024. PMID: 38724462 Free PMC article.