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AVE0118, blocker of the transient outward current (I(to)) and ultrarapid delayed rectifier current (I(Kur)), fully restores atrial contractility after cardioversion of atrial fibrillation in the goat.
de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M, Schotten U. de Haan S, et al. Among authors: van hunnik a. Circulation. 2006 Sep 19;114(12):1234-42. doi: 10.1161/CIRCULATIONAHA.106.630905. Epub 2006 Aug 28. Circulation. 2006. PMID: 16940189
Loss of continuity in the thin epicardial layer because of endomysial fibrosis increases the complexity of atrial fibrillatory conduction.
Verheule S, Tuyls E, Gharaviri A, Hulsmans S, van Hunnik A, Kuiper M, Serroyen J, Zeemering S, Kuijpers NH, Schotten U. Verheule S, et al. Among authors: van hunnik a. Circ Arrhythm Electrophysiol. 2013 Feb;6(1):202-11. doi: 10.1161/CIRCEP.112.975144. Epub 2013 Feb 6. Circ Arrhythm Electrophysiol. 2013. PMID: 23390124
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