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Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice.
Ke YD, van Hummel A, Au C, Chan G, Lee WS, van der Hoven J, Przybyla M, Deng Y, Sabale M, Morey N, Bertz J, Feiten A, Ippati S, Stevens CH, Yang S, Gladbach A, Haass NK, Kril JJ, Blair IP, Delerue F, Ittner LM. Ke YD, et al. Among authors: van hummel a. Neuron. 2024 Apr 17;112(8):1249-1264.e8. doi: 10.1016/j.neuron.2024.01.022. Epub 2024 Feb 15. Neuron. 2024. PMID: 38366598
Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.
Ke YD, van Hummel A, Stevens CH, Gladbach A, Ippati S, Bi M, Lee WS, Krüger S, van der Hoven J, Volkerling A, Bongers A, Halliday G, Haass NK, Kiernan M, Delerue F, Ittner LM. Ke YD, et al. Among authors: van der hoven j, van hummel a. Acta Neuropathol. 2015 Nov;130(5):661-78. doi: 10.1007/s00401-015-1486-0. Epub 2015 Oct 5. Acta Neuropathol. 2015. PMID: 26437864
Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia.
Przybyla M, Stevens CH, van der Hoven J, Harasta A, Bi M, Ittner A, van Hummel A, Hodges JR, Piguet O, Karl T, Kassiou M, Housley GD, Ke YD, Ittner LM, van Eersel J. Przybyla M, et al. Among authors: van eersel j, van der hoven j, van hummel a. Neurosci Lett. 2016 Sep 19;631:24-29. doi: 10.1016/j.neulet.2016.08.007. Epub 2016 Aug 10. Neurosci Lett. 2016. PMID: 27521751
Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice.
Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay JP, Poljak A, Delerue F, Ke YD, Ittner LM. Ittner A, et al. Among authors: van der hoven j, van hummel a. Science. 2016 Nov 18;354(6314):904-908. doi: 10.1126/science.aah6205. Science. 2016. PMID: 27856911
Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.
van Hummel A, Chan G, van der Hoven J, Morsch M, Ippati S, Suh L, Bi M, Asih PR, Lee WS, Butler TA, Przybyla M, Halliday GM, Piguet O, Kiernan MC, Chung RS, Ittner LM, Ke YD. van Hummel A, et al. Among authors: van der hoven j. Am J Pathol. 2018 Jun;188(6):1447-1456. doi: 10.1016/j.ajpath.2018.03.002. Epub 2018 Mar 22. Am J Pathol. 2018. PMID: 29577934 Free article.
Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice.
Brettle M, Stefen H, Djordjevic A, Fok SYY, Chan JW, van Hummel A, van der Hoven J, Przybyla M, Volkerling A, Ke YD, Delerue F, Ittner LM, Fath T. Brettle M, et al. Among authors: van der hoven j, van hummel a. Front Mol Neurosci. 2019 Sep 27;12:231. doi: 10.3389/fnmol.2019.00231. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31611772 Free PMC article.
Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature.
Przybyla M, van Eersel J, van Hummel A, van der Hoven J, Sabale M, Harasta A, Müller J, Gajwani M, Prikas E, Mueller T, Stevens CH, Power J, Housley GD, Karl T, Kassiou M, Ke YD, Ittner A, Ittner LM. Przybyla M, et al. Among authors: van hummel a. Brain. 2020 Jun 1;143(6):1889-1904. doi: 10.1093/brain/awaa133. Brain. 2020. PMID: 32375177
18 results