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Disease variants alter transcription factor levels and methylation of their binding sites.
Bonder MJ, Luijk R, Zhernakova DV, Moed M, Deelen P, Vermaat M, van Iterson M, van Dijk F, van Galen M, Bot J, Slieker RC, Jhamai PM, Verbiest M, Suchiman HE, Verkerk M, van der Breggen R, van Rooij J, Lakenberg N, Arindrarto W, Kielbasa SM, Jonkers I, van 't Hof P, Nooren I, Beekman M, Deelen J, van Heemst D, Zhernakova A, Tigchelaar EF, Swertz MA, Hofman A, Uitterlinden AG, Pool R, van Dongen J, Hottenga JJ, Stehouwer CD, van der Kallen CJ, Schalkwijk CG, van den Berg LH, van Zwet EW, Mei H, Li Y, Lemire M, Hudson TJ; BIOS Consortium; Slagboom PE, Wijmenga C, Veldink JH, van Greevenbroek MM, van Duijn CM, Boomsma DI, Isaacs A, Jansen R, van Meurs JB, 't Hoen PA, Franke L, Heijmans BT. Bonder MJ, et al. Among authors: van t hof p, van duijn cm, van heemst d, van dijk f, van den berg lh, van rooij j, van meurs jb, van dongen j, van der kallen cj, van der breggen r, van iterson m, van zwet ew, van greevenbroek mm, van galen m. Nat Genet. 2017 Jan;49(1):131-138. doi: 10.1038/ng.3721. Epub 2016 Dec 5. Nat Genet. 2017. PMID: 27918535
Variation in the SHC1 gene and longevity in humans.
Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Eline Slagboom P, Westendorp RG; 'Long Life' Study Group. Mooijaart SP, et al. Among authors: van heemst d, van gerwen s. Exp Gerontol. 2004 Feb;39(2):263-8. doi: 10.1016/j.exger.2003.10.001. Exp Gerontol. 2004. PMID: 15036421
Reduced insulin/IGF-1 signalling and human longevity.
van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG. van Heemst D, et al. Aging Cell. 2005 Apr;4(2):79-85. doi: 10.1111/j.1474-9728.2005.00148.x. Aging Cell. 2005. PMID: 15771611 Free article.
ApoE plasma levels and risk of cardiovascular mortality in old age.
Mooijaart SP, Berbée JF, van Heemst D, Havekes LM, de Craen AJ, Slagboom PE, Rensen PC, Westendorp RG. Mooijaart SP, et al. Among authors: van heemst d. PLoS Med. 2006 Jun;3(6):e176. doi: 10.1371/journal.pmed.0030176. Epub 2006 May 9. PLoS Med. 2006. PMID: 16671834 Free PMC article.
Liver X receptor alpha associates with human life span.
Mooijaart SP, Kuningas M, Westendorp RG, Houwing-Duistermaat JJ, Slagboom PE, Rensen PC, van Heemst D. Mooijaart SP, et al. Among authors: van heemst d. J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):343-9. doi: 10.1093/gerona/62.4.343. J Gerontol A Biol Sci Med Sci. 2007. PMID: 17452725
306 results