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Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis.
Hutter S, van Haaften WT, Hünerwadel A, Baebler K, Herfarth N, Raselli T, Mamie C, Misselwitz B, Rogler G, Weder B, Dijkstra G, Meier CF, de Vallière C, Weber A, Imenez Silva PH, Wagner CA, Frey-Wagner I, Ruiz PA, Hausmann M. Hutter S, et al. Among authors: van haaften wt. J Crohns Colitis. 2018 Nov 15;12(11):1348-1358. doi: 10.1093/ecco-jcc/jjy118. J Crohns Colitis. 2018. PMID: 30165600
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.
Raselli T, Wyss A, Gonzalez Alvarado MN, Weder B, Mamie C, Spalinger MR, Van Haaften WT, Dijkstra G, Sailer AW, Imenez Silva PH, Wagner CA, Tosevski V, Leibl S, Scharl M, Rogler G, Hausmann M, Misselwitz B. Raselli T, et al. Among authors: van haaften wt. J Crohns Colitis. 2019 Sep 19;13(9):1186-1200. doi: 10.1093/ecco-jcc/jjz039. J Crohns Colitis. 2019. PMID: 31220227 Free PMC article.
New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4.
Weder B, Schefer F, van Haaften WT, Patsenker E, Stickel F, Mueller S, Hutter S, Schuler C, Baebler K, Wang Y, Mamie C, Dijkstra G, de Vallière C, Imenez Silva PH, Wagner CA, Frey-Wagner I, Ruiz PA, Seuwen K, Rogler G, Hausmann M. Weder B, et al. Among authors: van haaften wt. Inflamm Bowel Dis. 2022 Jan 5;28(1):109-125. doi: 10.1093/ibd/izab140. Inflamm Bowel Dis. 2022. PMID: 34320209 Free article.
Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type III Collagen Are Novel Serological Biomarkers to Differentiate Crohn's Disease from Ulcerative Colitis.
Mortensen JH, Godskesen LE, Jensen MD, Van Haaften WT, Klinge LG, Olinga P, Dijkstra G, Kjeldsen J, Karsdal MA, Bay-Jensen AC, Krag A. Mortensen JH, et al. Among authors: van haaften wt. J Crohns Colitis. 2015 Oct;9(10):863-72. doi: 10.1093/ecco-jcc/jjv123. Epub 2015 Jul 17. J Crohns Colitis. 2015. PMID: 26188349 Clinical Trial.
Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease.
Lang BM, Biedermann L, van Haaften WT, de Vallière C, Schuurmans M, Begré S, Zeitz J, Scharl M, Turina M, Greuter T, Schreiner P, Heinrich H, Kuntzen T, Vavricka SR, Rogler G, Beerenwinkel N, Misselwitz B; Swiss IBD Cohort Study Group. Lang BM, et al. Among authors: van haaften wt. Aliment Pharmacol Ther. 2018 Jan;47(1):55-66. doi: 10.1111/apt.14378. Epub 2017 Oct 20. Aliment Pharmacol Ther. 2018. PMID: 29052254
Intestinal stenosis in Crohn's disease shows a generalized upregulation of genes involved in collagen metabolism and recognition that could serve as novel anti-fibrotic drug targets.
van Haaften WT, Blokzijl T, Hofker HS, Olinga P, Dijkstra G, Bank RA, Boersema M. van Haaften WT, et al. Therap Adv Gastroenterol. 2020 Aug 29;13:1756284820952578. doi: 10.1177/1756284820952578. eCollection 2020. Therap Adv Gastroenterol. 2020. PMID: 32922514 Free PMC article.
Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis.
Pachera E, Assassi S, Salazar GA, Stellato M, Renoux F, Wunderlin A, Blyszczuk P, Lafyatis R, Kurreeman F, de Vries-Bouwstra J, Messemaker T, Feghali-Bostwick CA, Rogler G, van Haaften WT, Dijkstra G, Oakley F, Calcagni M, Schniering J, Maurer B, Distler JH, Kania G, Frank-Bertoncelj M, Distler O. Pachera E, et al. Among authors: van haaften wt. J Clin Invest. 2020 Sep 1;130(9):4888-4905. doi: 10.1172/JCI135439. J Clin Invest. 2020. PMID: 32603313 Free PMC article.
15 results