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Translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system active drugs.
Ferreira GS, Dijkstra FM, Veening-Griffioen DH, Boon WPC, Schellekens H, Moors EHM, van Meer PJK, Stuurman FE, van Gerven JMA. Ferreira GS, et al. Among authors: van gerven jma. Transl Psychiatry. 2023 Mar 1;13(1):74. doi: 10.1038/s41398-023-02353-1. Transl Psychiatry. 2023. PMID: 36859342 Free PMC article. Review.
Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers.
Dijkstra FM, Zuiker RGJA, Siebenga PS, Leigh-Pemberton RA, Sun L, Manthis JD, de Kam ML, Lin R, von Moltke LL, Rezendes D, van Gerven JMA. Dijkstra FM, et al. Among authors: van gerven jma. Br J Clin Pharmacol. 2022 Jun;88(6):2909-2925. doi: 10.1111/bcp.15229. Epub 2022 Jan 31. Br J Clin Pharmacol. 2022. PMID: 35014069 Free PMC article.
Administration of oxathridine, a first-in-class histamine-3 receptor partial agonist in healthy male volunteers: Central nervous system depression and pseudo-hallucinations.
Dijkstra FM, Zuiker RGJA, Heuberger JAAC, Kanhai KMS, De Kam M, Duvauchelle T, Lecomte JM, Labeeuw O, Landais L, Ligneau X, Robert P, Capet M, Schwartz JC, van Gerven JMA. Dijkstra FM, et al. Among authors: van gerven jma. Br J Clin Pharmacol. 2024 Jan;90(1):321-335. doi: 10.1111/bcp.15910. Epub 2023 Oct 11. Br J Clin Pharmacol. 2024. PMID: 37724688 Clinical Trial.
174 results