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Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates.
van Geel R, Wijdeven MA, Heesbeen R, Verkade JM, Wasiel AA, van Berkel SS, van Delft FL. van Geel R, et al. Among authors: van delft fl, van berkel ss. Bioconjug Chem. 2015 Nov 18;26(11):2233-42. doi: 10.1021/acs.bioconjchem.5b00224. Epub 2015 Jun 10. Bioconjug Chem. 2015. PMID: 26061183 Free article.
Enzymatic glycan remodeling-metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering.
Wijdeven MA, van Geel R, Hoogenboom JH, Verkade JMM, Janssen BMG, Hurkmans I, de Bever L, van Berkel SS, van Delft FL. Wijdeven MA, et al. Among authors: van geel r. MAbs. 2022 Jan-Dec;14(1):2078466. doi: 10.1080/19420862.2022.2078466. MAbs. 2022. PMID: 35634725 Free PMC article.
Correction: Verkade, J.M.M.; et al. A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody-Drug Conjugates. Antibodies 2018, 7, 12.
Verkade JMM, Wijdeven MA, Van Geel R, Janssen BMG, Van Berkel SS, Van Delft FL; Antibodies Editorial Office. Verkade JMM, et al. Among authors: van delft fl, van geel r, van berkel ss. Antibodies (Basel). 2018 Aug 30;7(3):34. doi: 10.3390/antib7030034. Antibodies (Basel). 2018. PMID: 31544884 Free PMC article.
Detection of transglutaminase activity using click chemistry.
van Geel R, Debets MF, Löwik DW, Pruijn GJ, Boelens WC. van Geel R, et al. Amino Acids. 2012 Sep;43(3):1251-63. doi: 10.1007/s00726-011-1198-2. Epub 2011 Dec 17. Amino Acids. 2012. PMID: 22180026 Free PMC article.
The redox state of transglutaminase 2 controls arterial remodeling.
van den Akker J, VanBavel E, van Geel R, Matlung HL, Guvenc Tuna B, Janssen GM, van Veelen PA, Boelens WC, De Mey JG, Bakker EN. van den Akker J, et al. Among authors: van geel r, van veelen pa. PLoS One. 2011;6(8):e23067. doi: 10.1371/journal.pone.0023067. Epub 2011 Aug 25. PLoS One. 2011. PMID: 21901120 Free PMC article.
Osimertinib Plasma Trough Concentration in Relation to Brain Metastases Development in Patients With Advanced EGFR-Mutated NSCLC.
Gulikers JL, Veerman GDM, Jebbink M, Kruithof PD, Steendam CMJ, Boosman RJ, Mathijssen RHJ, Tjan-Heijnen VCG, Driessen JHM, Dursun S, Smit EF, Dingemans AC, van Geel RMJM, Croes S, Hendriks LEL. Gulikers JL, et al. Among authors: van geel rmjm. JTO Clin Res Rep. 2024 Feb 20;5(4):100656. doi: 10.1016/j.jtocrr.2024.100656. eCollection 2024 Apr. JTO Clin Res Rep. 2024. PMID: 38550297 Free PMC article.
Validated extended multiplexed LC-MS/MS assay for the quantification of adagrasib and sotorasib in human plasma, together with four additional SMIs.
Kruithof PD, de Beer YM, Gulikers JL, Stolk LML, Hendriks LEL, Croes S, van Geel RMJM. Kruithof PD, et al. Among authors: van geel rmjm. J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Dec 1;1231:123918. doi: 10.1016/j.jchromb.2023.123918. Epub 2023 Nov 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2023. PMID: 37979367 Free article.
46 results