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γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity.
Janssen A, Villacorta Hidalgo J, Beringer DX, van Dooremalen S, Fernando F, van Diest E, Terrizi AR, Bronsert P, Kock S, Schmitt-Gräff A, Werner M, Heise K, Follo M, Straetemans T, Sebestyen Z, Chudakov DM, Kasatskaya SA, Frenkel FE, Ravens S, Spierings E, Prinz I, Küppers R, Malkovsky M, Fisch P, Kuball J. Janssen A, et al. Among authors: van dooremalen s. Cancer Immunol Res. 2020 Apr;8(4):530-543. doi: 10.1158/2326-6066.CIR-19-0513. Epub 2020 Feb 4. Cancer Immunol Res. 2020. PMID: 32019779
TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice.
Johanna I, Hernández-López P, Heijhuurs S, Bongiovanni L, de Bruin A, Beringer D, van Dooremalen S, Shultz LD, Ishikawa F, Sebestyen Z, Straetemans T, Kuball J. Johanna I, et al. Among authors: van dooremalen s. J Leukoc Biol. 2020 Jun;107(6):1069-1079. doi: 10.1002/JLB.5MA0120-228R. Epub 2020 Feb 5. J Leukoc Biol. 2020. PMID: 32022317 Free PMC article.
Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds.
van Diest E, Hernández López P, Meringa AD, Vyborova A, Karaiskaki F, Heijhuurs S, Gumathi Bormin J, van Dooremalen S, Nicolasen MJT, Gatti LCDE, Johanna I, Straetemans T, Sebestyén Z, Beringer DX, Kuball J. van Diest E, et al. Among authors: van dooremalen s. J Immunother Cancer. 2021 Nov;9(11):e003850. doi: 10.1136/jitc-2021-003850. J Immunother Cancer. 2021. PMID: 34815357 Free PMC article.
Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.
Kierkels GJJ, van Diest E, Hernández-López P, Scheper W, de Bruin ACM, Frijlink E, Aarts-Riemens T, van Dooremalen SFJ, Beringer DX, Oostvogels R, Kramer L, Straetemans T, Uckert W, Sebestyén Z, Kuball J. Kierkels GJJ, et al. Among authors: van dooremalen sfj. Mol Ther Methods Clin Dev. 2021 Jun 24;22:388-400. doi: 10.1016/j.omtm.2021.06.011. eCollection 2021 Sep 10. Mol Ther Methods Clin Dev. 2021. PMID: 34514030 Free PMC article.
Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile.
van der Wagen LE, Miranda-Bedate A, Janssen A, Fernando F, Appukudige N, van Dooremalen S, Westinga K, Admiraal R, Lorenowicz MJ, Huls G, Janssen JJWM, Broers AEC, van der Velden WJFM, van Marwijk Kooy R, Hazenberg MD, de Haar C, Lindemans C, Jan Boelens J, Kuball J. van der Wagen LE, et al. Among authors: van dooremalen s. Bone Marrow Transplant. 2020 Nov;55(11):2188-2192. doi: 10.1038/s41409-020-0910-9. Epub 2020 Apr 28. Bone Marrow Transplant. 2020. PMID: 32346077 No abstract available.
Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations.
de Maat S, Björkqvist J, Suffritti C, Wiesenekker CP, Nagtegaal W, Koekman A, van Dooremalen S, Pasterkamp G, de Groot PG, Cicardi M, Renné T, Maas C. de Maat S, et al. Among authors: van dooremalen s. J Allergy Clin Immunol. 2016 Nov;138(5):1414-1423.e9. doi: 10.1016/j.jaci.2016.02.021. Epub 2016 Apr 6. J Allergy Clin Immunol. 2016. PMID: 27130860
Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity.
Hiemstra IH, Santegoets KCM, Janmaat ML, De Goeij BECG, Ten Hagen W, van Dooremalen S, Boross P, van den Brakel J, Bosgra S, Andringa G, van Kessel-Welmers B, Verzijl D, Hibbert RG, Frerichs KA, Mutis T, van de Donk NWCJ, Ahmadi T, Satijn D, Sasser AK, Breij ECW. Hiemstra IH, et al. Among authors: van dooremalen s. EBioMedicine. 2023 Jul;93:104663. doi: 10.1016/j.ebiom.2023.104663. Epub 2023 Jun 26. EBioMedicine. 2023. PMID: 37379657 Free PMC article.