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A small-molecule fusion inhibitor of influenza virus is orally active in mice.
Science. 2019 Mar 8;363(6431):eaar6221. doi: 10.1126/science.aar6221.
Science. 2019.
PMID: 30846569
Free PMC article.
Potent peptidic fusion inhibitors of influenza virus.
Kadam RU, Juraszek J, Brandenburg B, Buyck C, Schepens WBG, Kesteleyn B, Stoops B, Vreeken RJ, Vermond J, Goutier W, Tang C, Vogels R, Friesen RHE, Goudsmit J, van Dongen MJP, Wilson IA.
Kadam RU, et al. Among authors: van dongen mjp.
Science. 2017 Oct 27;358(6362):496-502. doi: 10.1126/science.aan0516. Epub 2017 Sep 28.
Science. 2017.
PMID: 28971971
Free PMC article.
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Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors.
Lange JH, Venhorst J, van Dongen MJ, Frankena J, Bassissi F, de Bruin NM, den Besten C, de Beer SB, Oostenbrink C, Markova N, Kruse CG.
Lange JH, et al.
Eur J Med Chem. 2011 Oct;46(10):4808-19. doi: 10.1016/j.ejmech.2011.04.023. Epub 2011 May 13.
Eur J Med Chem. 2011.
PMID: 21880399
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N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT₆R) antagonists with unique structural features.
van Loevezijn A, Venhorst J, Iwema Bakker WI, de Korte CG, de Looff W, Verhoog S, van Wees JW, van Hoeve M, van de Woestijne RP, van der Neut MA, Borst AJ, van Dongen MJ, de Bruin NM, Keizer HG, Kruse CG.
van Loevezijn A, et al.
J Med Chem. 2011 Oct 27;54(20):7030-54. doi: 10.1021/jm200466r. Epub 2011 Sep 26.
J Med Chem. 2011.
PMID: 21866910
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Site-selective labeling strategies for screening by NMR.
Weigelt J, Wikström M, Schultz J, van Dongen MJ.
Weigelt J, et al.
Comb Chem High Throughput Screen. 2002 Dec;5(8):623-30. doi: 10.2174/1386207023329978.
Comb Chem High Throughput Screen. 2002.
PMID: 12470259
Review.
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Structure-based screening as applied to human FABP4: a highly efficient alternative to HTS for hit generation.
van Dongen MJ, Uppenberg J, Svensson S, Lundbäck T, Akerud T, Wikström M, Schultz J.
van Dongen MJ, et al.
J Am Chem Soc. 2002 Oct 9;124(40):11874-80. doi: 10.1021/ja017830c.
J Am Chem Soc. 2002.
PMID: 12358531
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