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Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV.
Okba NMA, Widjaja I, van Dieren B, Aebischer A, van Amerongen G, de Waal L, Stittelaar KJ, Schipper D, Martina B, van den Brand JMA, Beer M, Bosch BJ, Haagmans BL. Okba NMA, et al. Among authors: van dieren b. Emerg Microbes Infect. 2020 Dec;9(1):1080-1091. doi: 10.1080/22221751.2020.1760735. Emerg Microbes Infect. 2020. PMID: 32471334 Free PMC article.
Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection.
Stalin Raj V, Okba NMA, Gutierrez-Alvarez J, Drabek D, van Dieren B, Widagdo W, Lamers MM, Widjaja I, Fernandez-Delgado R, Sola I, Bensaid A, Koopmans MP, Segalés J, Osterhaus ADME, Bosch BJ, Enjuanes L, Haagmans BL. Stalin Raj V, et al. Among authors: van dieren b. Sci Adv. 2018 Aug 8;4(8):eaas9667. doi: 10.1126/sciadv.aas9667. eCollection 2018 Aug. Sci Adv. 2018. PMID: 30101189 Free PMC article.
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.
Widjaja I, Wang C, van Haperen R, Gutiérrez-Álvarez J, van Dieren B, Okba NMA, Raj VS, Li W, Fernandez-Delgado R, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ. Widjaja I, et al. Among authors: van dieren b. Emerg Microbes Infect. 2019;8(1):516-530. doi: 10.1080/22221751.2019.1597644. Emerg Microbes Infect. 2019. PMID: 30938227 Free PMC article.
Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.
Li W, Hulswit RJG, Widjaja I, Raj VS, McBride R, Peng W, Widagdo W, Tortorici MA, van Dieren B, Lang Y, van Lent JWM, Paulson JC, de Haan CAM, de Groot RJ, van Kuppeveld FJM, Haagmans BL, Bosch BJ. Li W, et al. Among authors: van dieren b. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8508-E8517. doi: 10.1073/pnas.1712592114. Epub 2017 Sep 18. Proc Natl Acad Sci U S A. 2017. PMID: 28923942 Free PMC article.
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies.
Wang C, van Haperen R, Gutiérrez-Álvarez J, Li W, Okba NMA, Albulescu I, Widjaja I, van Dieren B, Fernandez-Delgado R, Sola I, Hurdiss DL, Daramola O, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ. Wang C, et al. Among authors: van dieren b. Nat Commun. 2021 Mar 17;12(1):1715. doi: 10.1038/s41467-021-21968-w. Nat Commun. 2021. PMID: 33731724 Free PMC article.