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Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes.
Thielen NGM, van Caam APM, V Beuningen HM, Vitters EL, van den Bosch MHJ, Koenders MI, van de Loo FAJ, Blaney Davidson EN, van der Kraan PM. Thielen NGM, et al. Among authors: van caam apm. Osteoarthritis Cartilage. 2023 Nov;31(11):1481-1490. doi: 10.1016/j.joca.2023.08.004. Epub 2023 Aug 29. Osteoarthritis Cartilage. 2023. PMID: 37652257 Free article.
TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?
Blaney Davidson EN, van Caam AP, Vitters EL, Bennink MB, Thijssen E, van den Berg WB, Koenders MI, van Lent PL, van de Loo FA, van der Kraan PM. Blaney Davidson EN, et al. Osteoarthritis Cartilage. 2015 Mar;23(3):478-86. doi: 10.1016/j.joca.2014.12.005. Epub 2014 Dec 18. Osteoarthritis Cartilage. 2015. PMID: 25529198 Free article.
Osteoarthritis year in review 2016: biology.
Blaney Davidson EN, van Caam AP, van der Kraan PM. Blaney Davidson EN, et al. Osteoarthritis Cartilage. 2017 Feb;25(2):175-180. doi: 10.1016/j.joca.2016.09.024. Epub 2017 Jan 16. Osteoarthritis Cartilage. 2017. PMID: 28100421 Free article. Review.
IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3.
van Geffen EW, van Caam APM, Schreurs W, van de Loo FA, van Lent PLEM, Koenders MI, Thudium CS, Bay-Jensen AC, Blaney Davidson EN, van der Kraan PM. van Geffen EW, et al. Among authors: van der kraan pm, van caam apm, van de loo fa, van lent plem. Osteoarthritis Cartilage. 2019 Jan;27(1):148-157. doi: 10.1016/j.joca.2018.08.016. Epub 2018 Sep 7. Osteoarthritis Cartilage. 2019. PMID: 30201492 Free article.
Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-β-mediated IL-6 receptor suppression.
Wiegertjes R, Thielen NGM, van Caam APM, van Laar M, van Beuningen HM, Koenders MI, van Lent PLEM, van der Kraan PM, van de Loo FAJ, Blaney Davidson EN. Wiegertjes R, et al. Among authors: van caam apm. Osteoarthritis Cartilage. 2021 May;29(5):773-782. doi: 10.1016/j.joca.2021.01.008. Epub 2021 Feb 20. Osteoarthritis Cartilage. 2021. PMID: 33617971 Free article.
Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage.
Blaney Davidson EN, Vitters EL, Bennink MB, van Lent PL, van Caam AP, Blom AB, van den Berg WB, van de Loo FA, van der Kraan PM. Blaney Davidson EN, et al. Ann Rheum Dis. 2015 Jun;74(6):1257-64. doi: 10.1136/annrheumdis-2013-204528. Epub 2014 Jan 21. Ann Rheum Dis. 2015. PMID: 24448347
IL37 dampens the IL1β-induced catabolic status of human OA chondrocytes.
van Geffen EW, van Caam AP, van Beuningen HM, Vitters EL, Schreurs W, van de Loo FA, van Lent PL, Koenders MI, Blaney Davidson EN, van der Kraan PM. van Geffen EW, et al. Rheumatology (Oxford). 2017 Mar 1;56(3):351-361. doi: 10.1093/rheumatology/kew411. Rheumatology (Oxford). 2017. PMID: 27940589
TGFβ/BMP Signaling Pathway in Cartilage Homeostasis.
Thielen NGM, van der Kraan PM, van Caam APM. Thielen NGM, et al. Among authors: van caam apm. Cells. 2019 Aug 24;8(9):969. doi: 10.3390/cells8090969. Cells. 2019. PMID: 31450621 Free PMC article. Review.
26 results