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Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates.
van Geel R, Wijdeven MA, Heesbeen R, Verkade JM, Wasiel AA, van Berkel SS, van Delft FL. van Geel R, et al. Among authors: van delft fl, van berkel ss. Bioconjug Chem. 2015 Nov 18;26(11):2233-42. doi: 10.1021/acs.bioconjchem.5b00224. Epub 2015 Jun 10. Bioconjug Chem. 2015. PMID: 26061183 Free article.
Enzymatic glycan remodeling-metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering.
Wijdeven MA, van Geel R, Hoogenboom JH, Verkade JMM, Janssen BMG, Hurkmans I, de Bever L, van Berkel SS, van Delft FL. Wijdeven MA, et al. Among authors: van berkel ss. MAbs. 2022 Jan-Dec;14(1):2078466. doi: 10.1080/19420862.2022.2078466. MAbs. 2022. PMID: 35634725 Free PMC article.
Correction: Verkade, J.M.M.; et al. A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody-Drug Conjugates. Antibodies 2018, 7, 12.
Verkade JMM, Wijdeven MA, Van Geel R, Janssen BMG, Van Berkel SS, Van Delft FL; Antibodies Editorial Office. Verkade JMM, et al. Among authors: van berkel ss. Antibodies (Basel). 2018 Aug 30;7(3):34. doi: 10.3390/antib7030034. Antibodies (Basel). 2018. PMID: 31544884 Free PMC article.
Metal-free bioconjugation reactions.
van Berkel SS, van Delft FL. van Berkel SS, et al. Among authors: van delft fl. Drug Discov Today Technol. 2013 Spring;10(1):e45-51. doi: 10.1016/j.ddtec.2012.10.011. Drug Discov Today Technol. 2013. PMID: 24050229 Review.
Synthesis of DIBAC analogues with excellent SPAAC rate constants.
Debets MF, Prins JS, Merkx D, van Berkel SS, van Delft FL, van Hest JC, Rutjes FP. Debets MF, et al. Among authors: van delft fl, van hest jc, van berkel ss. Org Biomol Chem. 2014 Jul 21;12(27):5031-7. doi: 10.1039/c4ob00694a. Org Biomol Chem. 2014. PMID: 24899166
A macrocyclic coumarin-containing tripeptide via CuAAC chemistry.
van Berkel SS, van der Lee B, van Delft FL, Rutjes FP. van Berkel SS, et al. Among authors: van delft fl, van der lee b. Chem Commun (Camb). 2009 Jul 28;(28):4272-4. doi: 10.1039/b906762k. Epub 2009 Jun 9. Chem Commun (Camb). 2009. PMID: 19585044
Bioconjugation with strained alkenes and alkynes.
Debets MF, van Berkel SS, Dommerholt J, Dirks AT, Rutjes FP, van Delft FL. Debets MF, et al. Among authors: van delft fl, van berkel ss. Acc Chem Res. 2011 Sep 20;44(9):805-15. doi: 10.1021/ar200059z. Epub 2011 Jul 18. Acc Chem Res. 2011. PMID: 21766804
35 results