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Assay platform for clinically relevant metallo-β-lactamases.
van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. van Berkel SS, et al. J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23898798 Free PMC article.
Binding of (5S)-penicilloic acid to penicillin binding protein 3.
van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ. van Berkel SS, et al. ACS Chem Biol. 2013 Oct 18;8(10):2112-6. doi: 10.1021/cb400200h. Epub 2013 Aug 15. ACS Chem Biol. 2013. PMID: 23899657
Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure determination, table of crystallographic data, table of crystallographic parameters and refinement statistics, figures showing binding mode and distances, procedures for mass spectrometry measurements, differential scanning fluorimetry measurements, stopped-flow measurements and other kinetics measurements. See DOI: 10.1039/c4sc01752hClick here for additional data file.
Brem J, Struwe WB, Rydzik AM, Tarhonskaya H, Pfeffer I, Flashman E, van Berkel SS, Spencer J, Claridge TD, McDonough MA, Benesch JL, Schofield CJ. Brem J, et al. Among authors: van berkel ss. Chem Sci. 2015 Feb 19;6(2):956-963. doi: 10.1039/c4sc01752h. Epub 2014 Nov 4. Chem Sci. 2015. PMID: 25717359 Free PMC article.
Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.
Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ. Brem J, et al. Among authors: van berkel ss. Antimicrob Agents Chemother. 2015 Oct 19;60(1):142-50. doi: 10.1128/AAC.01335-15. Print 2016 Jan. Antimicrob Agents Chemother. 2015. PMID: 26482303 Free PMC article.
Staudinger ligation as a method for bioconjugation.
van Berkel SS, van Eldijk MB, van Hest JC. van Berkel SS, et al. Among authors: van eldijk mb, van hest jc. Angew Chem Int Ed Engl. 2011 Sep 12;50(38):8806-27. doi: 10.1002/anie.201008102. Epub 2011 Sep 2. Angew Chem Int Ed Engl. 2011. PMID: 21887733 Review.
35 results