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The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers.
Zanetti-Domingues LC, Korovesis D, Needham SR, Tynan CJ, Sagawa S, Roberts SK, Kuzmanic A, Ortiz-Zapater E, Jain P, Roovers RC, Lajevardipour A, van Bergen En Henegouwen PMP, Santis G, Clayton AHA, Clarke DT, Gervasio FL, Shan Y, Shaw DE, Rolfe DJ, Parker PJ, Martin-Fernandez ML. Zanetti-Domingues LC, et al. Among authors: van bergen en henegouwen pmp. Nat Commun. 2018 Oct 18;9(1):4325. doi: 10.1038/s41467-018-06632-0. Nat Commun. 2018. PMID: 30337523 Free PMC article.
Nanobodies in therapeutic applications.
Roovers RC, van Dongen GA, van Bergen en Henegouwen PM. Roovers RC, et al. Curr Opin Mol Ther. 2007 Aug;9(4):327-35. Curr Opin Mol Ther. 2007. PMID: 17694445 Review.
EGF induces coalescence of different lipid rafts.
Hofman EG, Ruonala MO, Bader AN, van den Heuvel D, Voortman J, Roovers RC, Verkleij AJ, Gerritsen HC, van Bergen En Henegouwen PM. Hofman EG, et al. J Cell Sci. 2008 Aug 1;121(Pt 15):2519-28. doi: 10.1242/jcs.028753. Epub 2008 Jul 15. J Cell Sci. 2008. PMID: 18628305
Downregulation of EGFR by a novel multivalent nanobody-liposome platform.
Oliveira S, Schiffelers RM, van der Veeken J, van der Meel R, Vongpromek R, van Bergen En Henegouwen PM, Storm G, Roovers RC. Oliveira S, et al. J Control Release. 2010 Jul 14;145(2):165-75. doi: 10.1016/j.jconrel.2010.03.020. Epub 2010 Mar 31. J Control Release. 2010. PMID: 20362020
A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth.
Roovers RC, Vosjan MJ, Laeremans T, el Khoulati R, de Bruin RC, Ferguson KM, Verkleij AJ, van Dongen GA, van Bergen en Henegouwen PM. Roovers RC, et al. Int J Cancer. 2011 Oct 15;129(8):2013-24. doi: 10.1002/ijc.26145. Epub 2011 Aug 8. Int J Cancer. 2011. PMID: 21520037 Free PMC article.
144 results