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Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis.
Sci Rep. 2023 Sep 16;13(1):15406. doi: 10.1038/s41598-023-42152-8.
Sci Rep. 2023.
PMID: 37717068
Free PMC article.
The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam.
van Alen I, Chikunova A, Safeer AA, Ahmad MUD, Perrakis A, Ubbink M.
van Alen I, et al.
Biochemistry. 2021 Jul 20;60(28):2236-2245. doi: 10.1021/acs.biochem.1c00168. Epub 2021 Jul 12.
Biochemistry. 2021.
PMID: 34250791
Free PMC article.
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Asp179 in the class A β-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis.
van Alen I, Chikunova A, van Zanten DB, de Block AA, Timmer M, Brünle S, Ubbink M.
van Alen I, et al.
FEBS J. 2023 Oct;290(20):4933-4949. doi: 10.1111/febs.16892. Epub 2023 Jul 2.
FEBS J. 2023.
PMID: 37335937
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Characterization of the pathophysiological determinants of diarrheagenic Escherichia coli infection using a challenge model in healthy adults.
van Hoffen E, Mercenier A, Vidal K, Benyacoub J, Schloesser J, Kardinaal A, Lucas-van de Bos E, van Alen I, Roggero I, Duintjer K, Berendts A, Albers R, Kleerebezem M, Ten Bruggencate S.
van Hoffen E, et al. Among authors: van alen i.
Sci Rep. 2021 Mar 15;11(1):6060. doi: 10.1038/s41598-021-85161-1.
Sci Rep. 2021.
PMID: 33723346
Free PMC article.
Clinical Trial.
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Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus.
Huijbers MME, van Alen I, Wu JW, Barendregt A, Heck AJR, van Berkel WJH.
Huijbers MME, et al. Among authors: van alen i.
Molecules. 2018 Jan 16;23(1):184. doi: 10.3390/molecules23010184.
Molecules. 2018.
PMID: 29337919
Free PMC article.
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