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Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.
Murray-Stewart T, Dunworth M, Lui Y, Giardiello FM, Woster PM, Casero RA Jr. Murray-Stewart T, et al. PLoS One. 2018 Aug 23;13(8):e0202677. doi: 10.1371/journal.pone.0202677. eCollection 2018. PLoS One. 2018. PMID: 30138353 Free PMC article.
These studies provide insight into the polyamine-related mechanisms involved in the cancer cell response to curcumin and its potential as a chemopreventive or chemotherapeutic agent in the GI tract....
These studies provide insight into the polyamine-related mechanisms involved in the cancer cell response to curcumin and its potential as a …
Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis.
Cruz-Correa M, Hylind LM, Marrero JH, Zahurak ML, Murray-Stewart T, Casero RA Jr, Montgomery EA, Iacobuzio-Donahue C, Brosens LA, Offerhaus GJ, Umar A, Rodriguez LM, Giardiello FM. Cruz-Correa M, et al. Among authors: murray stewart t. Gastroenterology. 2018 Sep;155(3):668-673. doi: 10.1053/j.gastro.2018.05.031. Epub 2018 May 23. Gastroenterology. 2018. PMID: 29802852 Free PMC article. Clinical Trial.
Patients were randomly assigned (1:1) to groups given 100% pure curcumin (1,500 mg orally, twice per day) or identical-appearing placebo capsules for 12 months. The number and size of lower gastrointestinal tract polyps were evaluated every 4 months for 1 year. The primary …
Patients were randomly assigned (1:1) to groups given 100% pure curcumin (1,500 mg orally, twice per day) or identical-appearing placebo cap …