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1993 3
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19 results

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Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.
White AD, Peña KA, Clark LJ, Maria CS, Liu S, Jean-Alphonse FG, Lee JY, Lei S, Cheng Z, Tu CL, Fang F, Szeto N, Gardella TJ, Xiao K, Gellman SH, Bahar I, Sutkeviciute I, Chang W, Vilardaga JP. White AD, et al. Sci Signal. 2021 Oct 5;14(703):eabc5944. doi: 10.1126/scisignal.abc5944. Epub 2021 Oct 5. Sci Signal. 2021. PMID: 34609896 Free PMC article.
PTH(7d) stabilized a unique active PTHR conformation that mediated sustained cAMP signaling at the plasma membrane due to impaired beta-arrestin coupling to the receptor. Experiments in cells and mice revealed that sustained cAMP production by cell surface PTHR failed to m …
PTH(7d) stabilized a unique active PTHR conformation that mediated sustained cAMP signaling at the plasma membrane due to impaired beta-a …
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis.
Porter RF, Szczesniak AM, Toguri JT, Gebremeskel S, Johnston B, Lehmann C, Fingerle J, Rothenhäusler B, Perret C, Rogers-Evans M, Kimbara A, Nettekoven M, Guba W, Grether U, Ullmer C, Kelly MEM. Porter RF, et al. Molecules. 2019 Sep 13;24(18):3338. doi: 10.3390/molecules24183338. Molecules. 2019. PMID: 31540271 Free PMC article.
In silico molecular modelling and in vitro cell-based receptor assays were used to verify CB(2)R interactions, binding, cell signaling (ss-arrestin and cAMP) and early absorption, distribution, metabolism, excretion, and toxicology (ADMET) profiling of these receptor ligan …
In silico molecular modelling and in vitro cell-based receptor assays were used to verify CB(2)R interactions, binding, cell signaling (ss- …
beta-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinoma.
Marioni G, Nicolè L, Cappellesso R, Marchese-Ragona R, Fasanaro E, Di Carlo R, La Torre FB, Nardello E, Sanavia T, Ottaviano G, Fassina A. Marioni G, et al. Int J Biol Markers. 2019 Mar;34(1):33-40. doi: 10.1177/1724600818813621. Epub 2019 Mar 10. Int J Biol Markers. 2019. PMID: 30854928 Free article.
METHODS: The expression of beta-arrestin-1, E-cadherin, zeb1, and zeb2 was ascertained in 20 consecutive LSCCs. ...The combined effect of nicotine and beta-arrestin-1 was significantly associated with a shorter disease-free survival ( P=0.01) in our series of LSCC. …
METHODS: The expression of beta-arrestin-1, E-cadherin, zeb1, and zeb2 was ascertained in 20 consecutive LSCCs. ...The combined effec …
Heterogeneous hCG and hMG commercial preparations result in different intracellular signalling but induce a similar long-term progesterone response in vitro.
Riccetti L, Klett D, Ayoub MA, Boulo T, Pignatti E, Tagliavini S, Varani M, Trenti T, Nicoli A, Capodanno F, La Sala GB, Reiter E, Simoni M, Casarini L. Riccetti L, et al. Mol Hum Reprod. 2017 Oct 1;23(10):685-697. doi: 10.1093/molehr/gax047. Mol Hum Reprod. 2017. PMID: 29044421
Functional studies were performed in order to evaluate intracellular and total cAMP, progesterone production and beta-arrestin 2 recruitment by ELISA and BRET, in both human primary granulosa lutein cells (hGLC) and luteinizing hormone (LH)/hCG receptor (LHCGR)-transfected …
Functional studies were performed in order to evaluate intracellular and total cAMP, progesterone production and beta-arrestin 2 recr …
Mechanisms of endothelial cell dysfunction in cystic fibrosis.
Totani L, Plebani R, Piccoli A, Di Silvestre S, Lanuti P, Recchiuti A, Cianci E, Dell'Elba G, Sacchetti S, Patruno S, Guarnieri S, Mariggiò MA, Mari VC, Anile M, Venuta F, Del Porto P, Moretti P, Prioletta M, Mucilli F, Marchisio M, Pandolfi A, Evangelista V, Romano M. Totani L, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3243-3253. doi: 10.1016/j.bbadis.2017.08.011. Epub 2017 Aug 25. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28847515 Free article.
Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats.
Parreiras-E-Silva LT, Vargas-Pinilla P, Duarte DA, Longo D, Espinoza Pardo GV, Dulor Finkler A, Paixão-Côrtes VR, Paré P, Rovaris DL, Oliveira EB, Caceres RA, Gonçalves GL, Bouvier M, Salzano FM, Lucion AB, Costa-Neto CM, Bortolini MC. Parreiras-E-Silva LT, et al. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9044-9049. doi: 10.1073/pnas.1711687114. Epub 2017 Aug 7. Proc Natl Acad Sci U S A. 2017. PMID: 28784762 Free PMC article.
Here, we demonstrate that, compared with the Leu(8)OXT found in most placental mammals, the Cebidae Pro(8)OXT and Saguinus Val(3)Pro(8)OXT taxon-specific variants act as equi-efficacious agonists for the G(q)-dependent pathway but are weaker agonists for the beta-arrestin …
Here, we demonstrate that, compared with the Leu(8)OXT found in most placental mammals, the Cebidae Pro(8)OXT and Saguinus Val(3)Pro(8)OXT t …
Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor.
Di Benedetto A, Sun L, Zambonin CG, Tamma R, Nico B, Calvano CD, Colaianni G, Ji Y, Mori G, Grano M, Lu P, Colucci S, Yuen T, New MI, Zallone A, Zaidi M. Di Benedetto A, et al. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16502-7. doi: 10.1073/pnas.1419349111. Epub 2014 Nov 5. Proc Natl Acad Sci U S A. 2014. PMID: 25378700 Free PMC article.
We found that the passage of Oxtrs into the nucleus was facilitated by successive interactions with beta-arrestins (Arrbs), the small GTPase Rab5, importin-beta (Kpnb1), and transportin-1 (Tnpo1). siRNA-mediated knockdown of Arrb1, Arrb2, or Tnpo1 abrogated Oxt-induced exp …
We found that the passage of Oxtrs into the nucleus was facilitated by successive interactions with beta-arrestins (Arrbs), the small …
Does GRK-beta arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?
Daniele S, Trincavelli ML, Fumagalli M, Zappelli E, Lecca D, Bonfanti E, Campiglia P, Abbracchio MP, Martini C. Daniele S, et al. Cell Signal. 2014 Jun;26(6):1310-25. doi: 10.1016/j.cellsig.2014.02.016. Epub 2014 Mar 5. Cell Signal. 2014. PMID: 24613411
CysLT-mediated receptor desensitization mainly involved GRK2; this kinase, via a G protein-dependent mechanism, promoted a transient binding of the receptor to beta-arrestins, rapid ERK phosphorylation and sustained nuclear CREB activation. ...On the other hand, purinergic …
CysLT-mediated receptor desensitization mainly involved GRK2; this kinase, via a G protein-dependent mechanism, promoted a transient binding …
19 results