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Year Number of Results
2013 1
2014 30
2015 52
2016 107
2017 126
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2020 163
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2022 145
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1,119 results

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Page 1
Immune responses to stroke: mechanisms, modulation, and therapeutic potential.
Iadecola C, Buckwalter MS, Anrather J. Iadecola C, et al. J Clin Invest. 2020 Jun 1;130(6):2777-2788. doi: 10.1172/JCI135530. J Clin Invest. 2020. PMID: 32391806 Free PMC article. Review.
In the acute phase, innate immune cells invade brain and meninges and contribute to ischemic damage, but may also be protective. ...In the chronic phase, antigen presentation initiates an adaptive immune response targeted to the brain, which may underlie neuropsychi …
In the acute phase, innate immune cells invade brain and meninges and contribute to ischemic damage, but may also be protective. ...I …
Revisiting the neurovascular unit.
Schaeffer S, Iadecola C. Schaeffer S, et al. Nat Neurosci. 2021 Sep;24(9):1198-1209. doi: 10.1038/s41593-021-00904-7. Epub 2021 Aug 5. Nat Neurosci. 2021. PMID: 34354283 Free PMC article. Review.
The brain is supplied by an elaborate vascular network that originates extracranially and reaches deep into the brain. ...This concept has major implications for neurovascular regulation in health and disease and for brain imaging....
The brain is supplied by an elaborate vascular network that originates extracranially and reaches deep into the brain. ...This …
Therapeutic interventions in patients with prolonged disorders of consciousness.
Thibaut A, Schiff N, Giacino J, Laureys S, Gosseries O. Thibaut A, et al. Lancet Neurol. 2019 Jun;18(6):600-614. doi: 10.1016/S1474-4422(19)30031-6. Epub 2019 Apr 16. Lancet Neurol. 2019. PMID: 31003899 Free article. Review.
The management of patients with severe brain injuries and prolonged disorders of consciousness raises important issues particularly with respect to their therapeutic options. ...Most studies of interventions aimed at improving patients' level of consciousness and functiona …
The management of patients with severe brain injuries and prolonged disorders of consciousness raises important issues particularly w …
Inflammation and Stroke: An Overview.
Anrather J, Iadecola C. Anrather J, et al. Neurotherapeutics. 2016 Oct;13(4):661-670. doi: 10.1007/s13311-016-0483-x. Neurotherapeutics. 2016. PMID: 27730544 Free PMC article. Review.
While the immune response starts locally in occluded and hypoperfused vessels and the ischemic brain parenchyma, inflammatory mediators generated in situ propagate through the organism as a whole. ...In this overview we will outline the inflammatory cascade from its starti …
While the immune response starts locally in occluded and hypoperfused vessels and the ischemic brain parenchyma, inflammatory mediato …
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L. Tracy TE, et al. Cell. 2022 Feb 17;185(4):712-728.e14. doi: 10.1016/j.cell.2021.12.041. Epub 2022 Jan 20. Cell. 2022. PMID: 35063084 Free PMC article.
We showed that FTD mutations impair bioenergetics and markedly diminished Tau's interaction with mitochondria proteins, which were downregulated in AD brains of multiple cohorts and correlated with disease severity. These multimodal and dynamic Tau interactomes with exquis …
We showed that FTD mutations impair bioenergetics and markedly diminished Tau's interaction with mitochondria proteins, which were downregul …
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.
Iadecola C. Iadecola C. Neuron. 2017 Sep 27;96(1):17-42. doi: 10.1016/j.neuron.2017.07.030. Neuron. 2017. PMID: 28957666 Free PMC article. Review.
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress Review Group meeting of the National Institute of Neurological Disorders and Stroke, emphasizes the intimate relationship between the brain and its vessels. Since then, the NVU has attracte …
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress Review Group meeting of the National Institute of Neurol …
Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies.
Edlow BL, Claassen J, Schiff ND, Greer DM. Edlow BL, et al. Nat Rev Neurol. 2021 Mar;17(3):135-156. doi: 10.1038/s41582-020-00428-x. Epub 2020 Dec 14. Nat Rev Neurol. 2021. PMID: 33318675 Free PMC article. Review.
Substantial progress has been made over the past two decades in detecting, predicting and promoting recovery of consciousness in patients with disorders of consciousness (DoC) caused by severe brain injuries. Advanced neuroimaging and electrophysiological techniques have r …
Substantial progress has been made over the past two decades in detecting, predicting and promoting recovery of consciousness in patients wi …
Neurovascular and Cognitive Dysfunction in Hypertension.
Iadecola C, Gottesman RF. Iadecola C, et al. Circ Res. 2019 Mar 29;124(7):1025-1044. doi: 10.1161/CIRCRESAHA.118.313260. Circ Res. 2019. PMID: 30920929 Free PMC article. Review.
Furthermore, critical questions also concern whether treatment of hypertension prevents cognitive impairment, the blood pressure threshold for treatment, and the antihypertensive agents to be used. Recent advances in neurovascular biology, epidemiology, brain imaging, and …
Furthermore, critical questions also concern whether treatment of hypertension prevents cognitive impairment, the blood pressure threshold f …
Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells.
Benakis C, Brea D, Caballero S, Faraco G, Moore J, Murphy M, Sita G, Racchumi G, Ling L, Pamer EG, Iadecola C, Anrather J. Benakis C, et al. Nat Med. 2016 May;22(5):516-23. doi: 10.1038/nm.4068. Epub 2016 Mar 28. Nat Med. 2016. PMID: 27019327 Free PMC article.
Commensal gut bacteria impact the host immune system and can influence disease processes in several organs, including the brain. However, it remains unclear whether the microbiota has an impact on the outcome of acute brain injury. Here we show that antibiotic-induc …
Commensal gut bacteria impact the host immune system and can influence disease processes in several organs, including the brain. Howe …
Brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke.
Garcia-Bonilla L, Shahanoor Z, Sciortino R, Nazarzoda O, Racchumi G, Iadecola C, Anrather J. Garcia-Bonilla L, et al. bioRxiv [Preprint]. 2023 Apr 3:2023.03.31.535150. doi: 10.1101/2023.03.31.535150. bioRxiv. 2023. PMID: 37066298 Free PMC article. Updated. Preprint.
To address these limitations, we performed a longitudinal single-cell transcriptomic study of both brain and mouse blood to obtain a composite picture of brain-infiltrating leukocytes, circulating leukocytes, microglia and endothelium diversity over the ischemic/rep …
To address these limitations, we performed a longitudinal single-cell transcriptomic study of both brain and mouse blood to obtain a …
1,119 results