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Page 1
Histopathology, mRNA expression profile, and donor-derived cell-free DNA for assessment of rejection in pediatric heart transplantation.
O'Halloran CP, Tannous P, Arva NC, Thrush PT, Monge M, Joong A, Magnetta DA. O'Halloran CP, et al. Pediatr Transplant. 2024 May;28(3):e14705. doi: 10.1111/petr.14705. Pediatr Transplant. 2024. PMID: 38528753
BACKGROUND: The relationship between histopathologic and molecular ("MMDx") assessments of endomyocardial biopsy (EMB) and serum donor-derived cell-free DNA (ddcfDNA) in acute rejection (AR) assessment following pediatric heart transplantation (HT) is unknown. ...
BACKGROUND: The relationship between histopathologic and molecular ("MMDx") assessments of endomyocardial biopsy (EMB) and serum donor …
Immunoglobulin replacement products protect against SARS-CoV-2 infection in vivo despite poor neutralizing activity.
Zimmerman O, Altman Doss AM, Ying B, Liang CY, Mackin SR, Davis-Adams HG, Adams LJ, VanBlargan LA, Chen RE, Scheaffer SM, Desai P, Raju S, Mantia TL, O'Shaughnessy CC, Monroy JM, Wedner HJ, Rigell CJ, Kau AL, Dy TB, Ren Z, Turner JS, O'Halloran JA, Presti RM, Kendall PL, Fremont DH, Ellebedy AH, Diamond MS. Zimmerman O, et al. Among authors: o halloran ja. JCI Insight. 2024 Feb 8;9(3):e176359. doi: 10.1172/jci.insight.176359. JCI Insight. 2024. PMID: 38175703 Free PMC article.
Anti-spike antibody titers and neutralizing activity against SARS-CoV-2 WA1/2020 D614G increased gradually after the pandemic started and reached levels comparable to vaccinated healthy donors 18 months after the diagnosis of the first COVID-19 case in the United States in …
Anti-spike antibody titers and neutralizing activity against SARS-CoV-2 WA1/2020 D614G increased gradually after the pandemic started and re …
mRNA vaccine boosting enhances antibody responses against SARS-CoV-2 Omicron variant in individuals with antibody deficiency syndromes.
Zimmerman O, Altman Doss AM, Kaplonek P, Liang CY, VanBlargan LA, Chen RE, Monroy JM, Wedner HJ, Kulczycki A Jr, Mantia TL, O'Shaughnessy CC, Davis-Adams HG, Bertera HL, Adams LJ, Raju S, Zhao FR, Rigell CJ, Dy TB, Kau AL, Ren Z, Turner JS, O'Halloran JA, Presti RM, Fremont DH, Kendall PL, Ellebedy AH, Alter G, Diamond MS. Zimmerman O, et al. Among authors: o halloran ja. Cell Rep Med. 2022 Jun 21;3(6):100653. doi: 10.1016/j.xcrm.2022.100653. Epub 2022 Jun 9. Cell Rep Med. 2022. PMID: 35688161 Free PMC article.
Those vaccinated after SARS-CoV-2 infection develop higher and more sustained responses comparable with healthy donors. Most vaccinated individuals with PAD have serum-neutralizing antibody titers above an estimated correlate of protection against ancestral SARS-CoV-2 and …
Those vaccinated after SARS-CoV-2 infection develop higher and more sustained responses comparable with healthy donors. Most vaccinat …
Assessment of serological assays for identifying high titer convalescent plasma.
Farnsworth CW, Case JB, Hock K, Chen RE, O'Halloran JA, Presti R, Goss CW, Rauseo AM, Ellebedy A, Theel ES, Diamond MS, Henderson JP. Farnsworth CW, et al. Among authors: o halloran ja. Transfusion. 2021 Sep;61(9):2658-2667. doi: 10.1111/trf.16580. Epub 2021 Jul 6. Transfusion. 2021. PMID: 34216156 Free PMC article.
Relationships relative to FDA-approved cutoffs under the CCP emergency use authorization were identified in convalescent plasma from a cohort of 79 donors from April 2020. RESULTS: Relative to the neutralization assay, the spearman r value of the Ortho Clinical, Abbott, Ro …
Relationships relative to FDA-approved cutoffs under the CCP emergency use authorization were identified in convalescent plasma from a cohor …
Cellular and plasma proteomic determinants of COVID-19 and non-COVID-19 pulmonary diseases relative to healthy aging.
Arthur L, Esaulova E, Mogilenko DA, Tsurinov P, Burdess S, Laha A, Presti R, Goetz B, Watson MA, Goss CW, Gurnett CA, Mudd PA, Beers C, O'Halloran JA, Artyomov MN. Arthur L, et al. Among authors: o halloran ja. Nat Aging. 2021 Jun;1(6):535-549. doi: 10.1038/s43587-021-00067-x. Epub 2021 May 11. Nat Aging. 2021. PMID: 37117829
We examine the cellular and soluble determinants of coronavirus disease 2019 (COVID-19) relative to aging by performing mass cytometry in parallel with clinical blood testing and plasma proteomic profiling of ~4,700 proteins from 71 individuals with pulmonary disease and 148 heal …
We examine the cellular and soluble determinants of coronavirus disease 2019 (COVID-19) relative to aging by performing mass cytometry in pa …
Assessment of serological assays for identifying high titer convalescent plasma.
Farnsworth CW, Case JB, Hock K, Chen RE, O'Halloran JA, Presti R, Goss CW, Rauseo AM, Ellebedy A, Theel ES, Diamond MS, Henderson JP. Farnsworth CW, et al. Among authors: o halloran ja. medRxiv [Preprint]. 2021 Mar 28:2021.03.26.21254427. doi: 10.1101/2021.03.26.21254427. medRxiv. 2021. PMID: 33791711 Free PMC article. Updated. Preprint.
The purpose of this study was to establish correlations and analogous cutoffs between commercially available serological tests (Ortho, Abbott, Roche), a spike ELISA, and a virus neutralization assay using convalescent plasma from a cohort of 79 donors from April 2020. Rela …
The purpose of this study was to establish correlations and analogous cutoffs between commercially available serological tests (Ortho, Abbot …
CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14.
Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari J, Pang APS, Sugai C, Mahyari E, Francisco EB, Pise A, Rodrigues H, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Bimber BN, Plassmeyer M, Gupta R, Alpan O, O'Halloran JA, Mudd PA, Akalin E, Ndhlovu LC, Sacha JB. Patterson BK, et al. Among authors: o halloran ja. Int J Infect Dis. 2021 Feb;103:25-32. doi: 10.1016/j.ijid.2020.10.101. Epub 2020 Nov 10. Int J Infect Dis. 2021. PMID: 33186704 Free PMC article.
RESULTS: Over the 14-day study period, six patients survived, two were extubated, and one discharged. We observed complete CCR5 receptor occupancy in all donors by day 7. Compared with the baseline, we observed a concomitant statistically significant reduction in plasma IL …
RESULTS: Over the 14-day study period, six patients survived, two were extubated, and one discharged. We observed complete CCR5 receptor occ …
Hydrogels in adipose tissue engineering-Potential application in post-mastectomy breast regeneration.
O'Halloran NA, Dolan EB, Kerin MJ, Lowery AJ, Duffy GP. O'Halloran NA, et al. J Tissue Eng Regen Med. 2018 Dec;12(12):2234-2247. doi: 10.1002/term.2753. Epub 2018 Nov 8. J Tissue Eng Regen Med. 2018. PMID: 30334613 Review.
Hydrogels have been widely studied for their suitability for adipose tissue regeneration and are advantageous secondary to their ability to accurately imitate the native extracellular matrix. The aim of this review was to analyse the use of hydrogel scaffolds in the field …
Hydrogels have been widely studied for their suitability for adipose tissue regeneration and are advantageous secondary to their abil …
Recent Advances and Future Directions in Postmastectomy Breast Reconstruction.
O'Halloran N, Potter S, Kerin M, Lowery A. O'Halloran N, et al. Clin Breast Cancer. 2018 Aug;18(4):e571-e585. doi: 10.1016/j.clbc.2018.02.004. Epub 2018 Feb 27. Clin Breast Cancer. 2018. PMID: 29572079 Review.
Significant improvements have been made to existing implant and autologous methods of PMBR in recent decades in an effort to reduce donor site morbidity and complication rates and improve cosmesis. The limitations of contemporary methods of PMBR have directed research towa …
Significant improvements have been made to existing implant and autologous methods of PMBR in recent decades in an effort to reduce donor …
Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes.
Francis KR, Ton AN, Xin Y, O'Halloran PE, Wassif CA, Malik N, Williams IM, Cluzeau CV, Trivedi NS, Pavan WJ, Cho W, Westphal H, Porter FD. Francis KR, et al. Among authors: o halloran pe. Nat Med. 2016 Apr;22(4):388-96. doi: 10.1038/nm.4067. Epub 2016 Mar 21. Nat Med. 2016. PMID: 26998835 Free PMC article.
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