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Sphingolipids in Alzheimer's disease, how can we target them?
Crivelli SM, Giovagnoni C, Visseren L, Scheithauer AL, de Wit N, den Hoedt S, Losen M, Mulder MT, Walter J, de Vries HE, Bieberich E, Martinez-Martinez P. Crivelli SM, et al. Among authors: den hoedt s. Adv Drug Deliv Rev. 2020;159:214-231. doi: 10.1016/j.addr.2019.12.003. Epub 2020 Jan 3. Adv Drug Deliv Rev. 2020. PMID: 31911096 Review.
CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's disease.
Crivelli SM, Luo Q, Stevens JAA, Giovagnoni C, van Kruining D, Bode G, den Hoedt S, Hobo B, Scheithauer AL, Walter J, Mulder MT, Exley C, Mold M, Mielke MM, De Vries HE, Wouters K, van den Hove DLA, Berkes D, Ledesma MD, Verhaagen J, Losen M, Bieberich E, Martinez-Martinez P. Crivelli SM, et al. Among authors: den hoedt s. Alzheimers Res Ther. 2021 Feb 17;13(1):45. doi: 10.1186/s13195-021-00780-0. Alzheimers Res Ther. 2021. PMID: 33597019 Free PMC article.
FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4.
Crivelli SM, Luo Q, Kruining DV, Giovagnoni C, Mané-Damas M, den Hoedt S, Berkes D, De Vries HE, Mulder MT, Walter J, Waelkens E, Derua R, Swinnen JV, Dehairs J, Wijnands EPM, Bieberich E, Losen M, Martinez-Martinez P. Crivelli SM, et al. Among authors: den hoedt s. Biomed Pharmacother. 2022 Aug;152:113240. doi: 10.1016/j.biopha.2022.113240. Epub 2022 Jun 9. Biomed Pharmacother. 2022. PMID: 35689862 Free article.
Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.
de Wit NM, Snkhchyan H, den Hoedt S, Wattimena D, de Vos R, Mulder MT, Walter J, Martinez-Martinez P, Hoozemans JJ, Rozemuller AJ, de Vries HE. de Wit NM, et al. Among authors: den hoedt s. J Alzheimers Dis. 2017;60(3):795-807. doi: 10.3233/JAD-160551. J Alzheimers Dis. 2017. PMID: 27662305
Astrocytic ceramide as possible indicator of neuroinflammation.
de Wit NM, den Hoedt S, Martinez-Martinez P, Rozemuller AJ, Mulder MT, de Vries HE. de Wit NM, et al. Among authors: den hoedt s. J Neuroinflammation. 2019 Feb 25;16(1):48. doi: 10.1186/s12974-019-1436-1. J Neuroinflammation. 2019. PMID: 30803453 Free PMC article.
Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer's Disease and Control Mice.
den Hoedt S, Crivelli SM, Leijten FPJ, Losen M, Stevens JAA, Mané-Damas M, de Vries HE, Walter J, Mirzaian M, Sijbrands EJG, Aerts JMFG, Verhoeven AJM, Martinez-Martinez P, Mulder MT. den Hoedt S, et al. Front Aging Neurosci. 2021 Oct 27;13:765252. doi: 10.3389/fnagi.2021.765252. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34776936 Free PMC article.
Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis.
Leurs CE, Lopes Pinheiro MA, Wierts L, den Hoedt S, Mulder MT, Eijlers AJC, Schoonheim MM, Balk LJ, Uitdehaag BMJ, Killestein J, de Vries HE. Leurs CE, et al. Among authors: den hoedt s. Mult Scler Relat Disord. 2019 Feb;28:44-49. doi: 10.1016/j.msard.2018.11.024. Epub 2018 Nov 30. Mult Scler Relat Disord. 2019. PMID: 30553168
Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile: Findings From a Familial Hypercholesterolemia Pig Model.
Hoogendoorn A, den Hoedt S, Hartman EMJ, Krabbendam-Peters I, Te Lintel Hekkert M, van der Zee L, van Gaalen K, Witberg KT, Dorst K, Ligthart JMR, Drouet L, Van der Heiden K, van Lennep JR, van der Steen AFW, Duncker DJ, Mulder MT, Wentzel JJ. Hoogendoorn A, et al. Among authors: den hoedt s. Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2338-2352. doi: 10.1161/ATVBAHA.119.313246. Epub 2019 Sep 26. Arterioscler Thromb Vasc Biol. 2019. PMID: 31554418 Free PMC article.
16 results