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The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties.
Freire ER, Dhalia R, Moura DM, da Costa Lima TD, Lima RP, Reis CR, Hughes K, Figueiredo RC, Standart N, Carrington M, de Melo Neto OP. Freire ER, et al. Mol Biochem Parasitol. 2011 Mar;176(1):25-36. doi: 10.1016/j.molbiopara.2010.11.011. Epub 2010 Nov 24. Mol Biochem Parasitol. 2011. PMID: 21111007 Free PMC article.
The eIF4E subunits of two distinct trypanosomatid eIF4F complexes are subjected to differential post-translational modifications associated to distinct growth phases in culture.
Pereira MM, Malvezzi AM, Nascimento LM, Lima TD, Alves VS, Palma ML, Freire ER, Moura DM, Reis CR, de Melo Neto OP. Pereira MM, et al. Mol Biochem Parasitol. 2013 Aug;190(2):82-6. doi: 10.1016/j.molbiopara.2013.06.008. Epub 2013 Jul 15. Mol Biochem Parasitol. 2013. PMID: 23867205 Free article.
Trypanosoma brucei translation initiation factor homolog EIF4E6 forms a tripartite cytosolic complex with EIF4G5 and a capping enzyme homolog.
Freire ER, Malvezzi AM, Vashisht AA, Zuberek J, Saada EA, Langousis G, Nascimento JD, Moura D, Darzynkiewicz E, Hill K, de Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. Freire ER, et al. Eukaryot Cell. 2014 Jul;13(7):896-908. doi: 10.1128/EC.00071-14. Epub 2014 May 16. Eukaryot Cell. 2014. PMID: 24839125 Free PMC article.
eIF4F-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei.
Freire ER, Vashisht AA, Malvezzi AM, Zuberek J, Langousis G, Saada EA, Nascimento Jde F, Stepinski J, Darzynkiewicz E, Hill K, De Melo Neto OP, Wohlschlegel JA, Sturm NR, Campbell DA. Freire ER, et al. RNA. 2014 Aug;20(8):1272-86. doi: 10.1261/rna.045534.114. Epub 2014 Jun 24. RNA. 2014. PMID: 24962368 Free PMC article.
56 results