de Witte WEA - Search Results

1

Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules.

de Witte WEA, Avery LB, Mackness BC, Van Bogaert T, Park A, Sargentini-Maier ML. de Witte WEA, et al. J Pharmacokinet Pharmacodyn. 2023 Jun;50(3):229-241. doi: 10.1007/s10928-023-09849-9. Epub 2023 Mar 6. J Pharmacokinet Pharmacodyn. 2023. PMID: 36877385

2

The implications of target saturation for the use of drug-target residence time.

de Witte WEA, Danhof M, van der Graaf PH, de Lange ECM. de Witte WEA, et al. Nat Rev Drug Discov. 2018 Dec 28;18(1):82-84. doi: 10.1038/nrd.2018.234. Nat Rev Drug Discov. 2018. PMID: 30591716 No abstract available.

3

Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

de Witte WEA, Rottschäfer V, Danhof M, van der Graaf PH, Peletier LA, de Lange ECM. de Witte WEA, et al. J Pharmacokinet Pharmacodyn. 2018 Oct;45(5):763. doi: 10.1007/s10928-018-9604-y. J Pharmacokinet Pharmacodyn. 2018. PMID: 30171443 Free PMC article.

4

In vitro and in silico analysis of the effects of D₂ receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations.

de Witte WEA, Versfelt JW, Kuzikov M, Rolland S, Georgi V, Gribbon P, Gul S, Huntjens D, van der Graaf PH, Danhof M, Fernández-Montalván A, Witt G, de Lange ECM. de Witte WEA, et al. Br J Pharmacol. 2018 Nov;175(21):4121-4136. doi: 10.1111/bph.14456. Epub 2018 Sep 21. Br J Pharmacol. 2018. PMID: 30051456 Free PMC article.

5

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

de Witte WEA, Rottschäfer V, Danhof M, van der Graaf PH, Peletier LA, de Lange ECM. de Witte WEA, et al. J Pharmacokinet Pharmacodyn. 2018 Aug;45(4):621-635. doi: 10.1007/s10928-018-9593-x. Epub 2018 May 18. J Pharmacokinet Pharmacodyn. 2018. PMID: 29777407 Free PMC article.

6

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

Vlot AHC, de Witte WEA, Danhof M, van der Graaf PH, van Westen GJP, de Lange ECM. Vlot AHC, et al. Among authors: de witte wea. AAPS J. 2017 Dec 4;20(1):11. doi: 10.1208/s12248-017-0172-7. AAPS J. 2017. PMID: 29204742

7

From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action.

Nederpelt I, Kuzikov M, de Witte WEA, Schnider P, Tuijt B, Gul S, IJzerman AP, de Lange ECM, Heitman LH. Nederpelt I, et al. Among authors: de witte wea. Sci Rep. 2017 Oct 26;7(1):14169. doi: 10.1038/s41598-017-14257-4. Sci Rep. 2017. PMID: 29075004 Free PMC article.

8

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.

de Lange ECM, van den Brink W, Yamamoto Y, de Witte WEA, Wong YC. de Lange ECM, et al. Among authors: de witte wea. Expert Opin Drug Discov. 2017 Dec;12(12):1207-1218. doi: 10.1080/17460441.2017.1380623. Epub 2017 Sep 21. Expert Opin Drug Discov. 2017. PMID: 28933618 Review.

9

The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation.

de Witte WEA, Vauquelin G, van der Graaf PH, de Lange ECM. de Witte WEA, et al. Eur J Pharm Sci. 2017 Nov 15;109S:S83-S89. doi: 10.1016/j.ejps.2017.05.024. Epub 2017 May 12. Eur J Pharm Sci. 2017. PMID: 28502676 Free article.

10

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.

Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq SK, Bosma R, Nederpelt I, Heitman LH, Segala E, Amaral M, Guo D, Andres D, Georgi V, Stoddart LA, Hill S, Cooke RM, De Graaf C, Leurs R, Frech M, Wade RC, de Lange ECM, IJzerman AP, Müller-Fahrnow A, Ecker GF. Schuetz DA, et al. Among authors: de witte wea. Drug Discov Today. 2017 Jun;22(6):896-911. doi: 10.1016/j.drudis.2017.02.002. Epub 2017 Apr 13. Drug Discov Today. 2017. PMID: 28412474 Review.

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