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P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.
Martínez-García JJ, Martínez-Banaclocha H, Angosto-Bazarra D, de Torre-Minguela C, Baroja-Mazo A, Alarcón-Vila C, Martínez-Alarcón L, Amores-Iniesta J, Martín-Sánchez F, Ercole GA, Martínez CM, González-Lisorge A, Fernández-Pacheco J, Martínez-Gil P, Adriouch S, Koch-Nolte F, Luján J, Acosta-Villegas F, Parrilla P, García-Palenciano C, Pelegrin P. Martínez-García JJ, et al. Among authors: de torre minguela c. Nat Commun. 2019 Jun 20;10(1):2711. doi: 10.1038/s41467-019-10626-x. Nat Commun. 2019. PMID: 31221993 Free PMC article.
MCC950 closes the active conformation of NLRP3 to an inactive state.
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, de Torre-Minguela C, Cerón-Carrasco JP, Pérez-Sánchez H, Arostegui JI, Pelegrin P. Tapia-Abellán A, et al. Among authors: de torre minguela c. Nat Chem Biol. 2019 Jun;15(6):560-564. doi: 10.1038/s41589-019-0278-6. Epub 2019 May 13. Nat Chem Biol. 2019. PMID: 31086329 Free PMC article.
3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages.
Vasconcelos DP, de Torre-Minguela C, Gomez AI, Águas AP, Barbosa MA, Pelegrín P, Barbosa JN. Vasconcelos DP, et al. Among authors: de torre minguela c. Acta Biomater. 2019 Jun;91:123-134. doi: 10.1016/j.actbio.2019.04.035. Epub 2019 Apr 17. Acta Biomater. 2019. PMID: 31003033
Addendum: MCC950 closes the active conformation of NLRP3 to an inactive state.
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, de Torre-Minguela C, Cerón-Carrasco JP, Pérez-Sánchez H, Arostegui JI, Pelegrin P. Tapia-Abellán A, et al. Among authors: de torre minguela c. Nat Chem Biol. 2021 Mar;17(3):361. doi: 10.1038/s41589-021-00741-6. Nat Chem Biol. 2021. PMID: 33495649
P2X7 receptor activation impairs antitumour activity of natural killer cells.
Baroja-Mazo A, Peñín-Franch A, Lucas-Ruiz F, de Torre-Minguela C, Alarcón-Vila C, Hernández-Caselles T, Pelegrín P. Baroja-Mazo A, et al. Among authors: de torre minguela c. Br J Pharmacol. 2023 Jan;180(1):111-128. doi: 10.1111/bph.15951. Epub 2022 Oct 3. Br J Pharmacol. 2023. PMID: 36098250 Free PMC article.
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