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Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis.
Lecomte S, Devreux J, de Streel G, van Baren N, Havelange V, Schröder D, Vaherto N, Vanhaver C, Vanderaa C, Dupuis N, Pecquet C, Coulie PG, Constantinescu SN, Lucas S. Lecomte S, et al. Among authors: de streel g. Blood. 2023 Feb 2;141(5):490-502. doi: 10.1182/blood.2022017097. Blood. 2023. PMID: 36322928 Free PMC article.
Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer.
de Streel G, Bertrand C, Chalon N, Liénart S, Bricard O, Lecomte S, Devreux J, Gaignage M, De Boeck G, Mariën L, Van De Walle I, van der Woning B, Saunders M, de Haard H, Vermeersch E, Maes W, Deckmyn H, Coulie PG, van Baren N, Lucas S. de Streel G, et al. Nat Commun. 2020 Sep 11;11(1):4545. doi: 10.1038/s41467-020-17811-3. Nat Commun. 2020. PMID: 32917858 Free PMC article.
Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors.
Bertrand C, Van Meerbeeck P, de Streel G, Vaherto-Bleeckx N, Benhaddi F, Rouaud L, Noël A, Coulie PG, van Baren N, Lucas S. Bertrand C, et al. Among authors: de streel g. Front Immunol. 2021 Jul 27;12:704050. doi: 10.3389/fimmu.2021.704050. eCollection 2021. Front Immunol. 2021. PMID: 34386010 Free PMC article.