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Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.
Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, Birsoy K. Zhu XG, et al. Among authors: de stanchina e. Cell Metab. 2021 Jan 5;33(1):211-221.e6. doi: 10.1016/j.cmet.2020.10.017. Epub 2020 Nov 4. Cell Metab. 2021. PMID: 33152324 Free PMC article.
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J, Zhao C, Reznik E, Pasion JP, Kuo D, Mohan P, Wang S, Camarillo JM, Thomas PM, Jain N, Garcia-Bermudez J, Cho BK, Tam W, Kelleher NL, Socci N, Dogan A, De Stanchina E, Ciriello G, Green MR, Li S, Birsoy K, Melnick AM, Wendel HG. Parsa S, et al. Among authors: de stanchina e. Nat Cancer. 2020;1:653-664. doi: 10.1038/s43018-020-0080-0. Epub 2020 Jun 22. Nat Cancer. 2020. PMID: 33569544 Free PMC article.
Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor.
Russell J, Fanchon L, Alwaseem H, Molina H, O'Donoghue I, Bahr A, de Stanchina E, Pillarsetty N, Humm JL. Russell J, et al. Among authors: de stanchina e. Pharmacol Res Perspect. 2022 Apr;10(2):e00898. doi: 10.1002/prp2.898. Pharmacol Res Perspect. 2022. PMID: 35257504 Free PMC article.
Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia.
Garcia-Bermudez J, Badgley MA, Prasad S, Baudrier L, Liu Y, La K, Soula M, Williams RT, Yamaguchi N, Hwang RF, Taylor LJ, de Stanchina E, Rostandy B, Alwaseem H, Molina H, Bar-Sagi D, Birsoy K. Garcia-Bermudez J, et al. Among authors: de stanchina e. Nat Metab. 2022 Jun;4(6):724-738. doi: 10.1038/s42255-022-00583-z. Epub 2022 Jun 20. Nat Metab. 2022. PMID: 35726024 Free PMC article.
Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State.
Pitter KL, Grbovic-Huezo O, Joost S, Singhal A, Blum M, Wu K, Holm M, Ferrena A, Bhutkar A, Hudson A, Lecomte N, de Stanchina E, Chaligne R, Iacobuzio-Donahue CA, Pe'er D, Tammela T. Pitter KL, et al. Among authors: de stanchina e. Cancer Res. 2022 Oct 4;82(19):3549-3560. doi: 10.1158/0008-5472.CAN-22-1742. Cancer Res. 2022. PMID: 35952360 Free PMC article.
β4 Integrin signaling induces expansion of prostate tumor progenitors.
Yoshioka T, Otero J, Chen Y, Kim YM, Koutcher JA, Satagopan J, Reuter V, Carver B, de Stanchina E, Enomoto K, Greenberg NM, Scardino PT, Scher HI, Sawyers CL, Giancotti FG. Yoshioka T, et al. Among authors: de stanchina e. J Clin Invest. 2013 Feb;123(2):682-99. doi: 10.1172/JCI60720. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348745 Free PMC article.
Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts.
Laird J, Lok BH, Carney B, Kossatz S, de Stanchina E, Reiner T, Poirier JT, Rudin CM. Laird J, et al. Among authors: de stanchina e. J Thorac Oncol. 2019 Oct;14(10):1743-1752. doi: 10.1016/j.jtho.2019.05.032. Epub 2019 Jun 11. J Thorac Oncol. 2019. PMID: 31195178 Free PMC article.
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.
Sanghvi VR, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, Miele MM, Lailler N, Zhao C, de Stanchina E, Viale A, Akkari L, Lowe SW, Ciriello G, Hendrickson RC, Wendel HG. Sanghvi VR, et al. Among authors: de stanchina e. Cell. 2019 Aug 8;178(4):807-819.e21. doi: 10.1016/j.cell.2019.07.031. Cell. 2019. PMID: 31398338 Free PMC article.
243 results